羟丙甲糖在眼科中的应用

Q4 Medicine Oftalmologiya Pub Date : 2023-09-30 DOI:10.18008/1816-5095-2023-3-390-397
O. I. Butranova, S. K. Zyryanov
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引用次数: 0

摘要

眼部局部给药剂型是眼科患者管理的基础。眼睛是一种进化的结构,通过一些生理和解剖屏障来保护眼睛免受外来生物的影响。剂型的开发,由于包含特殊的赋形剂而有针对性地进入眼睛结构,旨在提高眼病患者的管理效率。眼科中最常用的赋形剂的作用机制决定了它们的有效性和安全性,并为各种剂型的开发奠定了基础。纤维素衍生物,由于其物理化学和药理学特性,是首选的群体之一,为开发外用剂型用于眼科。羟丙基甲基纤维素(羟丙基甲基纤维素)是研究最多的纤维素衍生物之一,其特点是活性物质(人工撕裂成分)和赋形剂适应症广泛。羟甲羟纤维素有利的药理学特性(长期暴露于有效浓度的眼科局部用药的能力,增加角膜水化程度的能力)有助于对该物质的积极研究,以评估其在新剂型(纳米颗粒)开发中的使用可能性,以及扩大现有适应症清单。本文综述了羟丙纤维素的临床和实验研究的有效性和安全性的分析。
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Hypromellose in Ophthalmology
Dosage forms for topical ocular administration are the basis of patient management in ophthalmology. The eye is a structure evolutionarily protected from the effects of xenobiotics by a number of physiological and anatomical barriers. The development of dosage forms, the targeted delivery into the eye structures is carried out due to the inclusion of special excipients, is aimed at improving the efficiency of managing patients with eye diseases. The action mechanisms of the most common groups of excipients used in ophthalmology underlie their effectiveness and safety, as well as create a basis for the various dosage forms development. Cellulose derivatives, due to their physicochemical and pharmacological characteristics, are one of the preferred groups for the development of topical dosage forms used in ophthalmology. Hypromellose (hydroxypropyl methylcellulose) is one of the most studied cellulose derivatives, which is characterized by a wide range of indications for both the active substance (artificial tear component) and the excipient. The favorable pharmacological properties of hypromellose (the ability to provide long-term exposure to effective concentrations of drugs used topically in ophthalmology, the ability to increase the degree of hydration of the cornea) contribute to the active study of this substance to assess the possibilities of its use in the development of new dosage forms (nanoparticles), as well as expanding the existing list of indications. This review is devoted to the analysis of clinical and experimental studies of the efficacy and safety of hypromellose.
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来源期刊
Oftalmologiya
Oftalmologiya Medicine-Ophthalmology
CiteScore
0.60
自引率
0.00%
发文量
93
审稿时长
8 weeks
期刊介绍: The scientific journal Oftalmologiya is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Ophthalmology, Физиология, Клиническая медицина, Профилактическая медицина, Медико-биологические науки, Фармацевтические науки. Before sending a scientific article, we recommend you to read the section For authors. This will allow you to prepare an article better for publication, to make it more interesting for the readers and useful for the scientific community. By following these steps, you will greatly increase the likelihood of your scientific article publishing in journals included in international citation systems (e.g., Scopus). Then you may choose a different journal, select the journal included to list of SAC Russia journal list, or send your scientific work for review and publication.
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