从日常到罕见——溃疡性坏疽性脓皮病1例报告

Erica Pham, Sarah B. W. Patton
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引用次数: 0

摘要

坏疽性脓皮病(Pyoderma gangrenosum, PG)是一种病因不明的非感染性中性粒细胞皮肤病。病变是由轻微事件引起的重大创伤,是PG的前兆事件。该病的流行病学显示,PG患者有与最常见的合并症相关的潜在疾病,如炎症性肠病、类风湿关节炎、血液学和实体器官恶性肿瘤。坏疽性脓皮病被认为是一种排除性诊断。它通常是一个漏诊导致治疗延误。临床医生可以使用的诊断指南是PARACELSUS评分。以下病例报告将集中在一个相对健康的50岁女性,既往有高血压病史,乳腺癌完全缓解。本病例强调了在无自身免疫性疾病史的患者鉴别诊断中保持PG的重要性。
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From Daily to Rarity - A Case Report of Ulcerative Pyoderma Gangrenosum
Pyoderma gangrenosum (PG) is classified as a non-infectious neutrophilic dermatosis with poorly understood etiology. Pathergy, which is major trauma caused by a minor incident, has been associated as a preceding event for PG. The epidemiology of the disease reveals patients who present with PG have associated underlying conditions with the most common comorbidities reported as inflammatory bowel disease, rheumatoid arthritis, hematological and solid organ malignancies. Pyoderma gangrenosum is considered a diagnosis of exclusion. It is commonly a missed diagnosis leading to delays in treatment. A diagnostic guide which clinicians can use is the PARACELSUS score. The following case report will focus on a relatively healthy 50-year-old female with a past medical history of hypertension who is in complete remission from breast cancer. This case highlights the importance of keeping PG in the differential diagnosis in patients without a history of autoimmune disease.
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