新型恶唑酮衍生物的设计、合成、表征及其非甾体抗炎活性

G. Muthubhupathi, M. Selvakumar, S. Navi Shree, C. Nisha, P. Sathiya Priya, P. A. Varshini
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引用次数: 0

摘要

通过苯甲酰甘氨酸晶体的制备和恶唑酮衍生物的合成,合成了一系列新的恶唑酮衍生物。合成的对氯苯醛、4-氟苯醛、肉桂醛、2-氯苯醛和O-茴香醛等化合物通过傅里叶变换红外光谱(FT-IR)进行了鉴定,并得到了相应的峰。通过蛋白质变性实验合成的化合物体外抗炎活性显示出非常好的显著抗炎活性。此外,与所有其他测试化合物相比,测试化合物2-氯苯甲醛具有最接近标准双氯芬酸钠的IC50值,并且在低浓度下显示出最高的抑制区,用于显示高效。
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Design, Synthesis, Characterization and Non-steroidal Anti-Inflammatory Activity of Novel Oxazolone Derivatives
An innovative sequence of Oxazolone derivatives were synthesized via chemical reaction including Preparation of benzoyl glycine crystals and Synthesis of oxazolone derivatives. The synthesized compounds such as P- Chlorobenaldehyde, 4-Fluro benaldehyde, Cinnamaldehyde, 2-Chloro benaldehyde, and O- Anisaldehyde were elucidated by Fourier Transform-Infra Red (FT-IR) spectrometer and showed its corresponding peaks. The in- vitro anti-inflammatory activity of synthesized compounds by protein denaturation assay exhibited very good significant anti-inflammatory activity. Additionally, the test compounds 2-Chloro benzaldehyde had nearest IC50 value to the standard diclofenac sodium when compared to all other test compounds, and demonstrated highest zone of inhibition at the low concentration used to exhibit the high potency.
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