草酸艾司西酞普兰及其在原料药和制剂中的联合应用分析综述

Dinesh B. Marathe, Rohini M. Koli, Kunal S. Mahajan, R. R. Patil, Vinod A. Chaure
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引用次数: 0

摘要

作为一种抗抑郁药,草酸艾司西酞普兰是西酞普兰的纯s -对映体衍生物,可阻断选择性血清素再摄取。通过阻止5 -羟色胺再摄取和提高突触间隙中的5 -羟色胺水平,这种作用具有抗抑郁作用。本综述确定了用于鉴定药物制剂中草酸艾司西酞普兰的分析方法,无论是单独使用还是与其他抗抑郁药联合使用。同时比较和讨论了18种分析技术,包括HPLC、HPTLC、稳定性指示策略、UV光谱、联用技术和生物分析方法,最好地证明了这一透彻的分析。分析开发必须经过验证,以便为监管文件提供可靠的结果。药物的发明给人类健康带来了一场革命。
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Analytical Review on Escitalopram oxalate and their combinations in Bulk and Pharmaceutical Formulation
As an antidepressant, escitalopram oxalate, a pure S-enantiomer derivative of citalopram, blocks selective serotonin reuptake. By preventing serotonin reuptake and boosting serotonin levels in synaptic clefts, this action exerts an antidepressant effect. The analytical method used to identify Escitalopram oxalate in pharmaceutical formulations, both alone and in combination with other antidepressants, was identified in this review. The simultaneous comparison and discussion of eighteen analytical techniques, including HPLC, HPTLC, stability-indicating strategies, UV spectroscopy, hyphenated techniques and bioanalytical procedures, is best demonstrated by this thorough analysis. Analytical development must be validated in order to produce reliable results for regulatory filings. The invention of drugs resulted in a revolution in human health.
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