Potential Role of Bromelain in Wound Healing Application: A Review

Bromelain is a proteolytic enzyme derived from the pineapple plant (Ananas comosus). Bromelain can be extracted from pineapple stems and fruits. Additionally, it can be derived from pineapple wastes such as the core, crown, and peel. Various extraction and purification methods such as reverse micellar system, aqueous two-phase system, chromatographic techniques, and membrane filtration have been used in order to produce high-qualitybromelain. Bromelain has been used clinically since 1876 and was first introduced as a therapeutic agent in 1957. Bromelain has gained increasing acceptance and compliance among patients as a phytotherapeutic drug due to its safety and lack of undesirable side effects. Bromelain is regarded as a nutrient that promotes wound healing due to the presence of several closely related proteinases that exhibit anti-inflammatory, fibrinolytic, and debridement properties.