{"title":"阿魏油胶树脂及其精油对去卵巢糖尿病大鼠的降糖作用研究","authors":"","doi":"10.56042/ijnpr.v14i3.4627","DOIUrl":null,"url":null,"abstract":"The aim of the present study was to evaluate the hypoglycemic activity of asafoetida and essential oil of asafoetida (EOA) in ovariectomised (OVX) diabetic rats. Twenty-four female rats were divided into four groups consisting of 6 rats in each group. OVX Control, OVX diabetic, OVX diabetic and asafoetida (25 mg/kg), OVX diabetic and EOA 25 μL/kg. Fasting Blood glucose, lipid profiles and liver indices were measured, and liver and kidney histopathology was investigated. Urine volume, urea, creatinine, and microalbumin were measured. The neuropathic damage was assessed by the hot plate method. The results showed that only in the asafoetida group the blood sugar, ALT and AST levels decreased significantly. Consumption of food, water, and body weight also decreased in the asafoetida grouponly. Also, regarding histology, relative improvement was observed in kidney and liver tissue in the asafoetida group. A significant decrease in urine volume and improvement in creatinine, urea and microalbumin concentrations, as well as improvement in hot plate test response time, were observed in both treatment groups. It can be concluded that asafoetida is effective in treating diabetes, but its essential oil has no effective activity on diabetes mellitus.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation of antidiabetic effect of Ferula assa-foetida oleo gum resin and its essential oil on ovariectomised diabetic rats\",\"authors\":\"\",\"doi\":\"10.56042/ijnpr.v14i3.4627\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of the present study was to evaluate the hypoglycemic activity of asafoetida and essential oil of asafoetida (EOA) in ovariectomised (OVX) diabetic rats. Twenty-four female rats were divided into four groups consisting of 6 rats in each group. OVX Control, OVX diabetic, OVX diabetic and asafoetida (25 mg/kg), OVX diabetic and EOA 25 μL/kg. Fasting Blood glucose, lipid profiles and liver indices were measured, and liver and kidney histopathology was investigated. Urine volume, urea, creatinine, and microalbumin were measured. The neuropathic damage was assessed by the hot plate method. The results showed that only in the asafoetida group the blood sugar, ALT and AST levels decreased significantly. Consumption of food, water, and body weight also decreased in the asafoetida grouponly. Also, regarding histology, relative improvement was observed in kidney and liver tissue in the asafoetida group. A significant decrease in urine volume and improvement in creatinine, urea and microalbumin concentrations, as well as improvement in hot plate test response time, were observed in both treatment groups. It can be concluded that asafoetida is effective in treating diabetes, but its essential oil has no effective activity on diabetes mellitus.\",\"PeriodicalId\":13297,\"journal\":{\"name\":\"Indian Journal of Natural Products and Resources\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Natural Products and Resources\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56042/ijnpr.v14i3.4627\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Natural Products and Resources","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56042/ijnpr.v14i3.4627","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
Investigation of antidiabetic effect of Ferula assa-foetida oleo gum resin and its essential oil on ovariectomised diabetic rats
The aim of the present study was to evaluate the hypoglycemic activity of asafoetida and essential oil of asafoetida (EOA) in ovariectomised (OVX) diabetic rats. Twenty-four female rats were divided into four groups consisting of 6 rats in each group. OVX Control, OVX diabetic, OVX diabetic and asafoetida (25 mg/kg), OVX diabetic and EOA 25 μL/kg. Fasting Blood glucose, lipid profiles and liver indices were measured, and liver and kidney histopathology was investigated. Urine volume, urea, creatinine, and microalbumin were measured. The neuropathic damage was assessed by the hot plate method. The results showed that only in the asafoetida group the blood sugar, ALT and AST levels decreased significantly. Consumption of food, water, and body weight also decreased in the asafoetida grouponly. Also, regarding histology, relative improvement was observed in kidney and liver tissue in the asafoetida group. A significant decrease in urine volume and improvement in creatinine, urea and microalbumin concentrations, as well as improvement in hot plate test response time, were observed in both treatment groups. It can be concluded that asafoetida is effective in treating diabetes, but its essential oil has no effective activity on diabetes mellitus.
期刊介绍:
Indian Journal of Natural Products and Resources (IJNPR), a quarterly journal, is dedicated to the exploration of topics that confront both educators, frontline workers in the fields, entrepreneurs and ultimate users of the value added products and their resources pertaining to both plants and animals. It publishes original research papers, reviews and short communications. The scope of the journal is multidisciplinary especially of applied nature. Papers on plant cultivation, fishery, apiary, poultry, dairy, disease and pest control measures, postharvest technology/practices, value added products and utilization of plants and animals in broader sense (including ethnobotany and pharmacology) are considered for publication.