榆平菇(Hypsizygus ulmarius, Bull.:Fr.)子实体和培养菌丝生物量的活性提取物可减轻Wistar大鼠酒精性肝损伤

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引用次数: 0

摘要

肝损伤是慢性酒精摄入的常见表现。酒精性肝病会导致一系列疾病,包括脂肪肝、肝炎和肝硬化。目前,这种情况没有理想的治疗方法。天然产物及其衍生物被认为是有前途的肝保护剂。蘑菇被认为是一种美味和丰富的生物活性化合物来源。因此,我们检测了食用菌土菌及其培养菌丝的水乙醇提取物的保肝活性。口服乙醇(36%,2 mL/ 100 g体重)30 d,引起肝损伤。水飞蓟素(100 mg/Kg体重)作为标准对照药。施用乙醇可显著提高血清谷氨酸草酰乙酸转氨酶、谷氨酸丙酮酸转氨酶和碱性磷酸酶。子实体生物活性提取物和培养菌丝处理显著降低肝损伤制造酶活性,提高肝组织超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽、谷胱甘肽-s转移酶活性,降低丙二醛水平。肝组织病理学观察,如减少小叶中心坏死、脂肪浸润和淋巴细胞浸润,也支持提取物的保护作用。结果表明,乌氏菌及其菌丝体的生物活性提取物对Wistar大鼠酒精性肝毒性具有明显的保护作用。研究结果表明,这种食用菌在改善酒精性肝损伤方面具有潜在的治疗作用。
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Bioactive extracts of fruiting bodies and cultured mycelia biomass of elm Oyster mushroom Hypsizygus ulmarius (Bull.:Fr.) alleviate alcohol-induced hepatic injury in Wistar rats
Hepatic injury is a common presentation of chronic alcohol intake. Alcohol liver diseases lead to a spectrum of diseases, including fatty liver, hepatitis and cirrhosis. Currently, no ideal treatment is available for this condition. Natural products and their derivatives are considered promising hepatoprotective agents. Mushrooms are considered a delicacy and rich source of bioactive compounds. Hence, we examined the hepatoprotective activity of aqueous ethanolic extracts of an edible mushroom, Hypsizygus ulmarius and its cultured mycelia. Hepatic damages were induced by oral administration of ethanol (36%, 2 mL/ 100 g body weight) for 30 days. Silymarin (100 mg/Kg body weight) was used as a standard reference drug. Administration of ethanol significantly elevated serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, and alkaline phosphatase. Treatment with the bioactive extracts of fruiting bodies and cultured mycelia significantly down-regulated activities of liver injury maker enzymes and elevated activities of superoxide dismutase, catalase, reduced glutathione, glutathione-s-transferase, and reduced the level of malondialdehyde in hepatic tissue. Histopathological observations of hepatic tissue, such as reduction in centrilobular necrosis, fatty infiltration and lymphocytic infiltration, also supported the protective effect of the extracts. The results thus indicated that bioactive extracts of H. ulmarius and its mycelia possessed a significant protective effect against alcohol-induced liver toxicity in Wistar rats. The findings suggested the potential therapeutic use of this edible mushroom for ameliorating alcohol-induced liver injury.
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来源期刊
CiteScore
1.00
自引率
12.50%
发文量
1
审稿时长
52 weeks
期刊介绍: Indian Journal of Natural Products and Resources (IJNPR), a quarterly journal, is dedicated to the exploration of topics that confront both educators, frontline workers in the fields, entrepreneurs and ultimate users of the value added products and their resources pertaining to both plants and animals. It publishes original research papers, reviews and short communications. The scope of the journal is multidisciplinary especially of applied nature. Papers on plant cultivation, fishery, apiary, poultry, dairy, disease and pest control measures, postharvest technology/practices, value added products and utilization of plants and animals in broader sense (including ethnobotany and pharmacology) are considered for publication.
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