药物输送研究领域的未来机遇

Joachim Kohn, Bozena Michniak-Kohn
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引用次数: 0

摘要

许多药物递送研究的重点都集中在癌症治疗的靶向药物递送和广泛的常用活性药物成分(api)的控制药物释放系统。在这篇“千字文章”中,我们重点介绍了一些新出现的健康威胁和药物输送研究的未来机会。重要的新出现的健康威胁包括COVID以外的病毒大流行、耐抗生素病原体、对新的抗真菌疗法的需求,以及由日益严重的污染和气候变化引起的新疾病。从根本上说,可能需要新的药物。例如,一项鲜为人知的研究工作侧重于开发基于金属-有机框架的新型抗生素。最后,需要新的交付方法。作为烧伤患者伤口敷料的局部肽递送系统的开发说明了这一点,该系统将生物技术(一种新型肽)与聚合物科学(一种新的局部递送系统)相结合,以解决目前尚无有效治疗方法的医疗需求(烧伤)。另一个重要的趋势是我们对影响的集体理解的转变,从“计算论文”转向考虑研究的社会效益,包括其商业化的潜力。为了在未来十年继续发挥作用,我们需要预测并迎接未来的挑战。这对年轻科学家来说尤其重要。
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Future Opportunities in the Field of Drug Delivery Research
Much of the priorities in drug delivery research are focused on targeted drug delivery for cancer therapies and a wide range of controlled drug release systems for commonly used active pharmaceutical ingredients (APIs). In this “thousand words article” we highlight some of the emerging health threats and future opportunities for drug delivery research. Important emerging health threats include viral pandemics beyond COVID, antibiotic-resistant pathogens, the need for new antifungal therapies, and emerging diseases caused by increasing pollution and climate change. Fundamentally new drugs may be needed. For example, one little known research effort focuses on the development of new antibiotics based on metal-organic frameworks. Finally, new delivery approaches will be needed. This is illustrated by the development of a topical peptide delivery system as a wound dressing for burn patients, combining biotechnology (a new peptide) with polymer science (a new topical delivery system) to address a medical need (burn injury) for which there is currently no effective treatment. Another important trend is the shift in our collective understanding of impact, moving away from “counting papers” to considering the societal benefit of the research including its potential for commercialization. To remain relevant in the coming decade, we need to anticipate and embrace future challenges. This is particularly important for younger scientists.
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发文量
23
审稿时长
10 weeks
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