Elin Uzunel MD , Ann-Charlotte Grahn Kronhed RPT, PhD , Christina Kaijser Alin RPT, PhD , Aisha Siddiqah Ahmed PhD , Per Wändell MD, PhD , Helena Salminen MD, PhD
{"title":"集体训练或脊柱矫形对骨质疏松症老年妇女生活质量和潜在疼痛血浆标志物的影响。随机对照试验","authors":"Elin Uzunel MD , Ann-Charlotte Grahn Kronhed RPT, PhD , Christina Kaijser Alin RPT, PhD , Aisha Siddiqah Ahmed PhD , Per Wändell MD, PhD , Helena Salminen MD, PhD","doi":"10.1016/j.arrct.2023.100297","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6).</p></div><div><h3>Design</h3><p>Randomized controlled trial.</p></div><div><h3>Setting</h3><p>Community-dwelling women in Stockholm.</p></div><div><h3>Participants</h3><p>A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113).</p></div><div><h3>Interventions</h3><p>The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months.</p></div><div><h3>Main Outcome Measure(s)</h3><p>QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms.</p></div><div><h3>Results</h3><p>No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women.</p></div><div><h3>Conclusion</h3><p>The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed.</p></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590109523000599/pdfft?md5=8b282daf529f4da8021983f302c4b7f4&pid=1-s2.0-S2590109523000599-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. 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Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6).</p></div><div><h3>Design</h3><p>Randomized controlled trial.</p></div><div><h3>Setting</h3><p>Community-dwelling women in Stockholm.</p></div><div><h3>Participants</h3><p>A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113).</p></div><div><h3>Interventions</h3><p>The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months.</p></div><div><h3>Main Outcome Measure(s)</h3><p>QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms.</p></div><div><h3>Results</h3><p>No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women.</p></div><div><h3>Conclusion</h3><p>The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. 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引用次数: 0
摘要
目的主要研究运动和使用脊柱矫形器对生活质量(QoL)的影响。其次,探讨上述干预措施对疼痛潜在标志物血浆水平的影响:P 物质(SP)、降钙素基因相关肽(CGRP)和白细胞介素-6(IL-6)。干预措施随机对照试验分为三组:参加器械锻炼组、使用激活脊柱矫形器治疗或对照组。干预时间为6个月。主要结果测量QoL(QUALEFFO-41和SF-36)、血浆中SP、CGRP和IL-6的水平,在基线时和6个月后在所有3组中进行测量。比较活动能力(QUALEFFO-41)的变化,脊柱矫形器组的最小二乘法效应低于对照组。在干预期间,锻炼组的角色情感评分(SF-36)有所下降。效应大小介于 0.02 和 0.6 之间。CGRP或SP的水平没有变化,而脊柱矫形器组的IL-6水平在6个月时低于其他组。46名女性中至少有1人通过X光检查证实曾发生过椎体骨折。干预措施对 QoL 没有影响或有负面影响,这出乎我们的意料。我们发现脊柱矫形器组的 IL-6 水平有所降低,但还需要更多的研究。
The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial
Objective
Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6).
Design
Randomized controlled trial.
Setting
Community-dwelling women in Stockholm.
Participants
A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113).
Interventions
The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months.
Main Outcome Measure(s)
QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms.
Results
No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women.
Conclusion
The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed.