基于昼夜滴定的正压通气治疗肥胖低通气综合征患者:一项随机对照试验

IF 1 Q4 CLINICAL NEUROLOGY Sleep Science Pub Date : 2023-09-01 DOI:10.1055/s-0043-1773790
Babak Amra, Marzieh Ghasemi, Forogh Soltaninejad, Mehrzad Salmasi
{"title":"基于昼夜滴定的正压通气治疗肥胖低通气综合征患者:一项随机对照试验","authors":"Babak Amra, Marzieh Ghasemi, Forogh Soltaninejad, Mehrzad Salmasi","doi":"10.1055/s-0043-1773790","DOIUrl":null,"url":null,"abstract":"Abstract Objectives The aim of the present study was to investigate the improvements of gas exchange and excessive daytime sleepiness in patients with obesity hypoventilation syndrome (OHS) in daytime and night-time split polysomnography (DSPSG and NSPSG). Materials and Methods In the present randomized controlled trial, patients with OHS were enrolled in two DSPSG (51 patients) and NSPSG (50 patients) groups in the Bamdad respiratory and sleep research center in Isfahan, Iran. In both groups, the diagnostic polysomnography (PSG) and titration were conducted in one session according to the guidelines of NSPSG. SpO2, PaCO2, and the Epworth Sleepiness Scale (ESS), were measured initially and 12 weeks after treatment. Furthermore, the PSG parameters and the type of treatments for the two groups were recorded and analyzed. Results A total of 101 OHS patients (age: 62.02 ± 12.4 year old; 61 females [60.4%]) were evaluated. There were no significant differences regarding BMI, gender, and AHI between groups (p > 0.05). Primary SpO2, PaCO2, and ESS were not significantly different between the two groups. After 12 weeks of treatment by continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BiPAP), there were significant improvement of SpO2, PaCO2, and ESS score (p < 0.001). The amount of change of these variables was not different between groups. Among all variables, only the lower SpO2 and higher PaCO2 were associated with response to BiPAP. Discussion There were no significant differences in the number of changes of SpO2, PaCO2, and ESS by treatment in the DSPSG and NSPSG groups. Therefore, DSPSG may be considered as a valuable alternative method for the diagnosis and titration in OHS patients. Clinical Trials IRCT20170512033930N2","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"38 1","pages":"0"},"PeriodicalIF":1.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Positive Pressure Ventilation Treatment Based on Daytime and Night-time Titration in Patients with Obesity Hypoventilation Syndrome: A Randomized Controlled Trial\",\"authors\":\"Babak Amra, Marzieh Ghasemi, Forogh Soltaninejad, Mehrzad Salmasi\",\"doi\":\"10.1055/s-0043-1773790\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Objectives The aim of the present study was to investigate the improvements of gas exchange and excessive daytime sleepiness in patients with obesity hypoventilation syndrome (OHS) in daytime and night-time split polysomnography (DSPSG and NSPSG). Materials and Methods In the present randomized controlled trial, patients with OHS were enrolled in two DSPSG (51 patients) and NSPSG (50 patients) groups in the Bamdad respiratory and sleep research center in Isfahan, Iran. In both groups, the diagnostic polysomnography (PSG) and titration were conducted in one session according to the guidelines of NSPSG. SpO2, PaCO2, and the Epworth Sleepiness Scale (ESS), were measured initially and 12 weeks after treatment. Furthermore, the PSG parameters and the type of treatments for the two groups were recorded and analyzed. Results A total of 101 OHS patients (age: 62.02 ± 12.4 year old; 61 females [60.4%]) were evaluated. There were no significant differences regarding BMI, gender, and AHI between groups (p > 0.05). Primary SpO2, PaCO2, and ESS were not significantly different between the two groups. After 12 weeks of treatment by continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BiPAP), there were significant improvement of SpO2, PaCO2, and ESS score (p < 0.001). The amount of change of these variables was not different between groups. Among all variables, only the lower SpO2 and higher PaCO2 were associated with response to BiPAP. Discussion There were no significant differences in the number of changes of SpO2, PaCO2, and ESS by treatment in the DSPSG and NSPSG groups. Therefore, DSPSG may be considered as a valuable alternative method for the diagnosis and titration in OHS patients. Clinical Trials IRCT20170512033930N2\",\"PeriodicalId\":21848,\"journal\":{\"name\":\"Sleep Science\",\"volume\":\"38 1\",\"pages\":\"0\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sleep Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0043-1773790\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0043-1773790","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

摘要目的探讨肥胖低通气综合征(OHS)患者在白天和夜间分割多导睡眠图(DSPSG和NSPSG)下气体交换和日间过度嗜睡的改善情况。材料与方法在本随机对照试验中,OHS患者被纳入伊朗伊斯法罕Bamdad呼吸与睡眠研究中心的DSPSG组(51例)和NSPSG组(50例)。两组均按照NSPSG指南进行诊断性多导睡眠图(PSG)和滴定术。治疗前和治疗后12周分别测量SpO2、PaCO2和Epworth嗜睡量表(ESS)。记录并分析两组患者PSG参数及治疗方式。结果101例OHS患者(年龄:62.02±12.4岁;61名女性(60.4%)被评估。两组间BMI、性别和AHI无显著差异(p >0.05)。两组间原发性SpO2、PaCO2、ESS差异无统计学意义。持续气道正压(CPAP)或双水平气道正压(BiPAP)治疗12周后,SpO2、PaCO2、ESS评分均有显著改善(p <0.001)。这些变量的变化量在组间没有差异。在所有变量中,只有较低的SpO2和较高的PaCO2与BiPAP的反应相关。DSPSG组与NSPSG组治疗前后SpO2、PaCO2、ESS变化数无显著差异。因此,DSPSG可能被认为是OHS患者诊断和滴定的有价值的替代方法。临床试验IRCT20170512033930N2
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Positive Pressure Ventilation Treatment Based on Daytime and Night-time Titration in Patients with Obesity Hypoventilation Syndrome: A Randomized Controlled Trial
Abstract Objectives The aim of the present study was to investigate the improvements of gas exchange and excessive daytime sleepiness in patients with obesity hypoventilation syndrome (OHS) in daytime and night-time split polysomnography (DSPSG and NSPSG). Materials and Methods In the present randomized controlled trial, patients with OHS were enrolled in two DSPSG (51 patients) and NSPSG (50 patients) groups in the Bamdad respiratory and sleep research center in Isfahan, Iran. In both groups, the diagnostic polysomnography (PSG) and titration were conducted in one session according to the guidelines of NSPSG. SpO2, PaCO2, and the Epworth Sleepiness Scale (ESS), were measured initially and 12 weeks after treatment. Furthermore, the PSG parameters and the type of treatments for the two groups were recorded and analyzed. Results A total of 101 OHS patients (age: 62.02 ± 12.4 year old; 61 females [60.4%]) were evaluated. There were no significant differences regarding BMI, gender, and AHI between groups (p > 0.05). Primary SpO2, PaCO2, and ESS were not significantly different between the two groups. After 12 weeks of treatment by continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BiPAP), there were significant improvement of SpO2, PaCO2, and ESS score (p < 0.001). The amount of change of these variables was not different between groups. Among all variables, only the lower SpO2 and higher PaCO2 were associated with response to BiPAP. Discussion There were no significant differences in the number of changes of SpO2, PaCO2, and ESS by treatment in the DSPSG and NSPSG groups. Therefore, DSPSG may be considered as a valuable alternative method for the diagnosis and titration in OHS patients. Clinical Trials IRCT20170512033930N2
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Sleep Science
Sleep Science CLINICAL NEUROLOGY-
CiteScore
2.50
自引率
12.50%
发文量
124
审稿时长
10 weeks
期刊最新文献
2024 Position Statement on the Use of Different Diagnostic Methods for Sleep Disorders in Adults - Brazilian Sleep Association. 2024 Standardization of Polysomnography Reports - A Consensus of the Brazilian Sleep Association. Association of Evening Eating with Sleep Quality and Insomnia among Adults in a Brazilian National Survey. Correction to: Can Improving Postoperative Sleep Speed Up Surgical Recovery?: Sleep Sci 2024; 17:3:335-338: São Paulo, September 20, 2024. Factors Related to the Sleep Duration of 3-Month-Old Infants.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1