Fatemeh Samandi ZADEH, Mohammad Kazem MOHAMMADI, Ayeh RAYATZADEH, Neda HASANZADEH
{"title":"Ag2O/GO/TiO2复合纳米结构1,4-二氢吡啶衍生物的合成及细胞毒活性评价","authors":"Fatemeh Samandi ZADEH, Mohammad Kazem MOHAMMADI, Ayeh RAYATZADEH, Neda HASANZADEH","doi":"10.33224/rrch.2022.67.10-12.07","DOIUrl":null,"url":null,"abstract":"Ag2O/GO/TiO2 composite nanostructure was established as a heterogeneous catalyst for the one pot synthesis of dihydropyridine derivatives via Hantzsch reaction. The synthetic method was mainly used in the presence of Ag2O/GO/TiO2 nano composite as a heterogeneous solid catalyst. This nano composite catalyzed Hantzsch reaction afforded good yields (87–95%) in solvent free condition at 90 °C. A broad range of structurally diverse aldehydes were applied successfully, and corresponding products were obtained in high yields without any byproduct. Compared with other methods, satisfactory results are obtained with high yields, short reaction times, and simplicity in the experimental procedure. Cytotoxic activities for some of the synthesized compounds were evaluated by MTT assay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in Raji cells. Diethyl 4-(2,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3 i) was found to be the most potent molecule among the studied 1, 4 dihydropyridines derivatives. Electron withdrawing groups along with heterocyclic rings bearing more hetero atoms seemed to be necessary factors in providing higher cytotoxic activities in Raji cell lines.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and cytotoxic activity evaluation of 1,4-dihydropyridine derivatives using Ag2O/GO/TiO2 composite nanostructure\",\"authors\":\"Fatemeh Samandi ZADEH, Mohammad Kazem MOHAMMADI, Ayeh RAYATZADEH, Neda HASANZADEH\",\"doi\":\"10.33224/rrch.2022.67.10-12.07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ag2O/GO/TiO2 composite nanostructure was established as a heterogeneous catalyst for the one pot synthesis of dihydropyridine derivatives via Hantzsch reaction. The synthetic method was mainly used in the presence of Ag2O/GO/TiO2 nano composite as a heterogeneous solid catalyst. This nano composite catalyzed Hantzsch reaction afforded good yields (87–95%) in solvent free condition at 90 °C. A broad range of structurally diverse aldehydes were applied successfully, and corresponding products were obtained in high yields without any byproduct. Compared with other methods, satisfactory results are obtained with high yields, short reaction times, and simplicity in the experimental procedure. Cytotoxic activities for some of the synthesized compounds were evaluated by MTT assay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in Raji cells. Diethyl 4-(2,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3 i) was found to be the most potent molecule among the studied 1, 4 dihydropyridines derivatives. Electron withdrawing groups along with heterocyclic rings bearing more hetero atoms seemed to be necessary factors in providing higher cytotoxic activities in Raji cell lines.\",\"PeriodicalId\":21323,\"journal\":{\"name\":\"Revue Roumaine De Chimie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2023-10-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revue Roumaine De Chimie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33224/rrch.2022.67.10-12.07\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue Roumaine De Chimie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33224/rrch.2022.67.10-12.07","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis and cytotoxic activity evaluation of 1,4-dihydropyridine derivatives using Ag2O/GO/TiO2 composite nanostructure
Ag2O/GO/TiO2 composite nanostructure was established as a heterogeneous catalyst for the one pot synthesis of dihydropyridine derivatives via Hantzsch reaction. The synthetic method was mainly used in the presence of Ag2O/GO/TiO2 nano composite as a heterogeneous solid catalyst. This nano composite catalyzed Hantzsch reaction afforded good yields (87–95%) in solvent free condition at 90 °C. A broad range of structurally diverse aldehydes were applied successfully, and corresponding products were obtained in high yields without any byproduct. Compared with other methods, satisfactory results are obtained with high yields, short reaction times, and simplicity in the experimental procedure. Cytotoxic activities for some of the synthesized compounds were evaluated by MTT assay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in Raji cells. Diethyl 4-(2,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3 i) was found to be the most potent molecule among the studied 1, 4 dihydropyridines derivatives. Electron withdrawing groups along with heterocyclic rings bearing more hetero atoms seemed to be necessary factors in providing higher cytotoxic activities in Raji cell lines.
期刊介绍:
The journal Revue Roumaine de Chimie (Roumanian Journal of Chemistry) was founded in 1956 under the name Revue de Chimie. Acad. R. P. R. from 1964, the title was modified in Revue Roumaine de Chimie (preserving the numbering of the volumes started in 1956). In 1997, the English translation of the title – Roumanian Journal of Chemistry – was also included on each issue.