Pub Date : 2023-10-23DOI: 10.33224/rrch.2022.67.10-12.06
Onur Kenan ULUTAŞ, Aysel BERKKAN
Detection, identification, and quantitation of alcohol in any matrix rich medium is a common practice although sample preparation is inevitable and time consuming. A sensitive, precise and ultimately wide range method for detection, identification and quantification of main content/residual/impurity alcohols without any matrix interference that can be used for production phase quality control, pharmaceutical and/or bio-technological refinement or toxicological evaluation and for forensics is always needed. Even for quality control also for toxicological considerations, ethanol (EtOH) and very similar compound methanol has to be detected and identified definitely becomes vital. However, with the fermented products, the matrix becomes a challenging process, makes the methods inefficient or more extraction methods have to be implanted. Here we propose a new simple and reliable direct extraction method has been developed for the determination of alcohol content of high matrix wine products using the gas-chromatography with flame ionization detector coupled to head space. The method was developed with a rich and complex component mixture of fermented alcoholic beverages (wine) with very high matrix effects. Isopropanol (IPA) was preferred as an internal standard, and Triton X-100 (TX-100) was used as diluting solution in this method. The amount of TX-100, extraction temperature, and the total volume of solution in head space vial (20 mL) were optimized. 2.5% TX-100, 80 °C extraction temperature, and 2.0 ml of total volume were used as optimum condition. Stationary phase was the fused silica, Agilent J&W DB-624 column (30 m x 320 m x 1.8 m) and Helium was used as a mobile phase. GC oven temperature programme was 40C (5 min), 5C/min ramp to 60C (0 min) and 30C/min to 150C (1 min). Performance of the method was assessed by evaluating the recovery, accuracy, precision, linearity, limits of detection (LOD) and limit of quantification (LOQ). Calibration curve was drawn between the concentration of 2.5% to 15.0% EtOH (y = 1.572x – 0.702, R² = 0.9960, y; the ratio of peak area of EtOH to IPA, x: EtOH%). The slopes of standard addition and external calibration curve were statistically same. Recovery of the method was 97.5 ± 3.5 for tree different concentrations and the precision was %5.8 (n= 11). LOD and LOQ were calculated as 0.80% and 2.5%, respectively. The proposed method has a potential for application into the industry and academia with determination of the alcohol content/residual/impurity and also check the quality and content of the fermented medium without the effect of matrix.
{"title":"A new direct extraction by gas-chromatography with flame ionization detector coupled to head space method for the determination of alcohol content of high matrix wine products","authors":"Onur Kenan ULUTAŞ, Aysel BERKKAN","doi":"10.33224/rrch.2022.67.10-12.06","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.06","url":null,"abstract":"Detection, identification, and quantitation of alcohol in any matrix rich medium is a common practice although sample preparation is inevitable and time consuming. A sensitive, precise and ultimately wide range method for detection, identification and quantification of main content/residual/impurity alcohols without any matrix interference that can be used for production phase quality control, pharmaceutical and/or bio-technological refinement or toxicological evaluation and for forensics is always needed. Even for quality control also for toxicological considerations, ethanol (EtOH) and very similar compound methanol has to be detected and identified definitely becomes vital. However, with the fermented products, the matrix becomes a challenging process, makes the methods inefficient or more extraction methods have to be implanted. Here we propose a new simple and reliable direct extraction method has been developed for the determination of alcohol content of high matrix wine products using the gas-chromatography with flame ionization detector coupled to head space. The method was developed with a rich and complex component mixture of fermented alcoholic beverages (wine) with very high matrix effects. Isopropanol (IPA) was preferred as an internal standard, and Triton X-100 (TX-100) was used as diluting solution in this method. The amount of TX-100, extraction temperature, and the total volume of solution in head space vial (20 mL) were optimized. 2.5% TX-100, 80 °C extraction temperature, and 2.0 ml of total volume were used as optimum condition. Stationary phase was the fused silica, Agilent J&W DB-624 column (30 m x 320 m x 1.8 m) and Helium was used as a mobile phase. GC oven temperature programme was 40C (5 min), 5C/min ramp to 60C (0 min) and 30C/min to 150C (1 min). Performance of the method was assessed by evaluating the recovery, accuracy, precision, linearity, limits of detection (LOD) and limit of quantification (LOQ). Calibration curve was drawn between the concentration of 2.5% to 15.0% EtOH (y = 1.572x – 0.702, R² = 0.9960, y; the ratio of peak area of EtOH to IPA, x: EtOH%). The slopes of standard addition and external calibration curve were statistically same. Recovery of the method was 97.5 ± 3.5 for tree different concentrations and the precision was %5.8 (n= 11). LOD and LOQ were calculated as 0.80% and 2.5%, respectively. The proposed method has a potential for application into the industry and academia with determination of the alcohol content/residual/impurity and also check the quality and content of the fermented medium without the effect of matrix.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.33224/rrch.2022.67.10-12.05
Abdenabi ABIDI, Mohamed DJERMANE, Mostepha IEZID, Noureddine GHERRAF, Maxime PONTIE
This study was aimed to implement response surface methodology to optimize the hydrodistillation parameters of the essential oil of the plant species Eucalyptus camaldulensis (RSM). The distillation time, condensation flow rate, and particle size were the desired parameters. To generate factor combinations, a three-factor Box-Behnken design was used. The response surface analysis yielded a linear model, which was used to calculate the top yield of extracted oil based on the optimized conditions. ANOVA shows that the generated polynomial model was highly noteworthy, with R2=0.861. The peak yield was 0.513663 % at the optimal conditions, which were 1mm as particle size, 3.4 mL/min as condensation flow rate, and 210 min as extraction time. The GC/MS analysis revealed the presence of p-cymene (26.22 %), spathulenol (16.71 %), and 1.8-cineole (14.44 %) as major components.
{"title":"Eco-extraction process of essential oil of the vegetal species Eucalyptus Camaldulensis Dehnh.: parametric modeling and optimization by Box-Behnken plan","authors":"Abdenabi ABIDI, Mohamed DJERMANE, Mostepha IEZID, Noureddine GHERRAF, Maxime PONTIE","doi":"10.33224/rrch.2022.67.10-12.05","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.05","url":null,"abstract":"This study was aimed to implement response surface methodology to optimize the hydrodistillation parameters of the essential oil of the plant species Eucalyptus camaldulensis (RSM). The distillation time, condensation flow rate, and particle size were the desired parameters. To generate factor combinations, a three-factor Box-Behnken design was used. The response surface analysis yielded a linear model, which was used to calculate the top yield of extracted oil based on the optimized conditions. ANOVA shows that the generated polynomial model was highly noteworthy, with R2=0.861. The peak yield was 0.513663 % at the optimal conditions, which were 1mm as particle size, 3.4 mL/min as condensation flow rate, and 210 min as extraction time. The GC/MS analysis revealed the presence of p-cymene (26.22 %), spathulenol (16.71 %), and 1.8-cineole (14.44 %) as major components.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.33224/rrch.2022.67.10-12.01
Sebnem SENOL, Emel AKYOL
The prime aims of the present work at formulating and preparing matrix tablets using Carbopol 974P to sustain the release of donepezil HCl. Tablets were prepared by direct compression method and evaluated for the effects of ingredients on the in-vitro release behavior. Gelatin, α-cellulose, sodium alginate, hydroxyapatite, and natural zeolite (clinoptilolite) were used as co-excipients to modulate the formulations. The prepared tablets of the 10 formulations were characterized by using Fourier transform infrared spectroscopy (FT-IR), digital microscope and scanning electron microscopy (SEM) techniques. The drug release kinetics was analyzed using Zero-order, First-order, Hixson-Crowell and Peppas models. The result indicated that the drug release rates highly depended on the polymers and pH medium. In addition, it was obtained that the combination of Carbopol 974P and gelatin retarded the drug release. So, these matrix tablets can reduce the dose intake. Thus, these matrix tablets are a promising release of donepezil HCl.
{"title":"In-vitro evaluation of co-excipients for release of donepezil hydrochloride from Carbopol 974P based tablets","authors":"Sebnem SENOL, Emel AKYOL","doi":"10.33224/rrch.2022.67.10-12.01","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.01","url":null,"abstract":"The prime aims of the present work at formulating and preparing matrix tablets using Carbopol 974P to sustain the release of donepezil HCl. Tablets were prepared by direct compression method and evaluated for the effects of ingredients on the in-vitro release behavior. Gelatin, α-cellulose, sodium alginate, hydroxyapatite, and natural zeolite (clinoptilolite) were used as co-excipients to modulate the formulations. The prepared tablets of the 10 formulations were characterized by using Fourier transform infrared spectroscopy (FT-IR), digital microscope and scanning electron microscopy (SEM) techniques. The drug release kinetics was analyzed using Zero-order, First-order, Hixson-Crowell and Peppas models. The result indicated that the drug release rates highly depended on the polymers and pH medium. In addition, it was obtained that the combination of Carbopol 974P and gelatin retarded the drug release. So, these matrix tablets can reduce the dose intake. Thus, these matrix tablets are a promising release of donepezil HCl.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.33224/rrch.2022.67.10-12.04
Daniela GHEORGHE, Ana NEACSU, Ancuta Mihaela SOFRONIA, Stefan PERISANU
"Solid-state thymol, liquid carvacrol and eugenol were characterized by using combustion calorimetry and thermal analysis-simultaneous thermogravimetry (TG) coupled with differential scanning calorimetry (DSC) techniques. The enthalpies of formation were calculated using the measured heat of combustion for the studied compounds. Our values were compared with the literature and calculated data. Information about the stability of the samples was reported. From DSC measurements, the temperatures of melting-decomposition and their corresponding enthalpies were calculated. "
{"title":"Thermodynamic properties of some monoterpenes with pharmacological applications","authors":"Daniela GHEORGHE, Ana NEACSU, Ancuta Mihaela SOFRONIA, Stefan PERISANU","doi":"10.33224/rrch.2022.67.10-12.04","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.04","url":null,"abstract":"\"Solid-state thymol, liquid carvacrol and eugenol were characterized by using combustion calorimetry and thermal analysis-simultaneous thermogravimetry (TG) coupled with differential scanning calorimetry (DSC) techniques. The enthalpies of formation were calculated using the measured heat of combustion for the studied compounds. Our values were compared with the literature and calculated data. Information about the stability of the samples was reported. From DSC measurements, the temperatures of melting-decomposition and their corresponding enthalpies were calculated. \"","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.33224/rrch.2022.67.10-12.07
Fatemeh Samandi ZADEH, Mohammad Kazem MOHAMMADI, Ayeh RAYATZADEH, Neda HASANZADEH
Ag2O/GO/TiO2 composite nanostructure was established as a heterogeneous catalyst for the one pot synthesis of dihydropyridine derivatives via Hantzsch reaction. The synthetic method was mainly used in the presence of Ag2O/GO/TiO2 nano composite as a heterogeneous solid catalyst. This nano composite catalyzed Hantzsch reaction afforded good yields (87–95%) in solvent free condition at 90 °C. A broad range of structurally diverse aldehydes were applied successfully, and corresponding products were obtained in high yields without any byproduct. Compared with other methods, satisfactory results are obtained with high yields, short reaction times, and simplicity in the experimental procedure. Cytotoxic activities for some of the synthesized compounds were evaluated by MTT assay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in Raji cells. Diethyl 4-(2,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3 i) was found to be the most potent molecule among the studied 1, 4 dihydropyridines derivatives. Electron withdrawing groups along with heterocyclic rings bearing more hetero atoms seemed to be necessary factors in providing higher cytotoxic activities in Raji cell lines.
{"title":"Synthesis and cytotoxic activity evaluation of 1,4-dihydropyridine derivatives using Ag2O/GO/TiO2 composite nanostructure","authors":"Fatemeh Samandi ZADEH, Mohammad Kazem MOHAMMADI, Ayeh RAYATZADEH, Neda HASANZADEH","doi":"10.33224/rrch.2022.67.10-12.07","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.07","url":null,"abstract":"Ag2O/GO/TiO2 composite nanostructure was established as a heterogeneous catalyst for the one pot synthesis of dihydropyridine derivatives via Hantzsch reaction. The synthetic method was mainly used in the presence of Ag2O/GO/TiO2 nano composite as a heterogeneous solid catalyst. This nano composite catalyzed Hantzsch reaction afforded good yields (87–95%) in solvent free condition at 90 °C. A broad range of structurally diverse aldehydes were applied successfully, and corresponding products were obtained in high yields without any byproduct. Compared with other methods, satisfactory results are obtained with high yields, short reaction times, and simplicity in the experimental procedure. Cytotoxic activities for some of the synthesized compounds were evaluated by MTT assay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in Raji cells. Diethyl 4-(2,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3 i) was found to be the most potent molecule among the studied 1, 4 dihydropyridines derivatives. Electron withdrawing groups along with heterocyclic rings bearing more hetero atoms seemed to be necessary factors in providing higher cytotoxic activities in Raji cell lines.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.33224/rrch.2022.67.10-12.02
M. Mazhar Abbas SHAHANI, Farzana AHMAD, Muhammad JAMIL, Musa Kaleem BALOCH
The quest for new nano-systems is ongoing to provide tailored nanoparticle systems for commercial purposes. The ability to manage their size and morphology leads to an advantage over other characteristics, therefore, a stable generation system is considered critical for their applications. We employed rose plant leaves extract to generate Ag-NPs via silver nitrate (AgNO3) as a basic ingredient in this study. The procedure was executed for multiple concentrations of the plant extract, as well as varying amounts of salt, and for different time periods. All of the different steps resulted in the development of Ag-NPs. The emergence of an absorption peak at 425 nm in UV-Vis spectroscopic spectra, and the presence of spherical particles visualized through SEM provided evidence of the creation of small-sized Ag-NPs. Finally, using the spread plate method, the antibacterial activity of Ag-NPs was investigated, and it was discovered that Ag-NPs exhibit high antibacterial activity against the four bacterial strains.
{"title":"An investigation into synthesis and characterization of Ag-nanoparticles using green chemistry, and their antibacterial properties","authors":"M. Mazhar Abbas SHAHANI, Farzana AHMAD, Muhammad JAMIL, Musa Kaleem BALOCH","doi":"10.33224/rrch.2022.67.10-12.02","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.02","url":null,"abstract":"The quest for new nano-systems is ongoing to provide tailored nanoparticle systems for commercial purposes. The ability to manage their size and morphology leads to an advantage over other characteristics, therefore, a stable generation system is considered critical for their applications. We employed rose plant leaves extract to generate Ag-NPs via silver nitrate (AgNO3) as a basic ingredient in this study. The procedure was executed for multiple concentrations of the plant extract, as well as varying amounts of salt, and for different time periods. All of the different steps resulted in the development of Ag-NPs. The emergence of an absorption peak at 425 nm in UV-Vis spectroscopic spectra, and the presence of spherical particles visualized through SEM provided evidence of the creation of small-sized Ag-NPs. Finally, using the spread plate method, the antibacterial activity of Ag-NPs was investigated, and it was discovered that Ag-NPs exhibit high antibacterial activity against the four bacterial strains.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.33224/rrch.2022.67.10-12.08
Mihai RĂDUCĂ, Ciprian I. Raț, Mihaela CRISTEA
The molecular structure of (Z)-2-phenyl-4-((4,6,8-trimethylazulen-1-yl)methylene)oxazol-5(4H)-one (1) was determined single-crystal X-ray diffraction. The crystal presents a monoclinic crystal system, space group P21/n, a = 7.0706(3) Å, b = 18.7978(7) Å, c = 13.7059(7) Å, β = 103.013(5) °, V = 1774.89(14) Å3. In the crystals of 1, are present strong π-π stacking interactions, with an average distance of 3.54 Å between centroids.
单晶x射线衍射测定了(Z)-2-苯基-4-((4,6,8-三甲基偶氮烯-1-基)亚甲基)恶唑-5(4H)- 1的分子结构。该晶体为单斜晶系，空间群P21/n, a = 7.0706(3) Å， b = 18.7978(7) Å， c = 13.7059(7) Å， β = 103.013(5)°，V = 1774.89(14) Å3。在1的晶体中，存在很强的π-π堆积相互作用，质心之间的平均距离为3.54 Å。
{"title":"Crystal structure and Hirshfeld surface analysis of (Z)-2-phenyl-4-((4,6,8-trimethylazulen-1-yl)methylene)oxazol-5(4H)-one","authors":"Mihai RĂDUCĂ, Ciprian I. Raț, Mihaela CRISTEA","doi":"10.33224/rrch.2022.67.10-12.08","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.08","url":null,"abstract":"The molecular structure of (Z)-2-phenyl-4-((4,6,8-trimethylazulen-1-yl)methylene)oxazol-5(4H)-one (1) was determined single-crystal X-ray diffraction. The crystal presents a monoclinic crystal system, space group P21/n, a = 7.0706(3) Å, b = 18.7978(7) Å, c = 13.7059(7) Å, β = 103.013(5) °, V = 1774.89(14) Å3. In the crystals of 1, are present strong π-π stacking interactions, with an average distance of 3.54 Å between centroids.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amygdalin (AMG) is mainly as an alternative therapy for traditional cancer treatment. In this study, an effective HPLC-DAD method was developed to investigate the extraction efficiency and determine AMG levels in fifteen fruit kernels belonging to different families. AMG in bitter almond was extracted from using various solvents by different extraction methods (Soxhlet, ultrasonic, orbital shaking and microwave extraction). The most suitable method was determined by the optimized HPLC-DAD method was applied to fifteen different fruit kernels. The recoveries were in the range 94.68% to 95.26%. The LOD and LOQ values were 0.0097 mg/g and 0.0295 mg/g, respectively. The amygdalin content in kernel fruits was determined ranging from 0.074 to 65.21 mg/g. This study showed that AMG was determined in a short time and with high yield, and the presence of AMG was proven in other fruit kernels belonging to different families that had not been proven before.
{"title":"Determination of amygdalin in fifteen different fruit kernels and extraction optimization","authors":"Busra Nagihan OZTURK, Serap AYAZ SEYHAN, Dilek BILGIC ALKAYA","doi":"10.33224/rrch.2022.67.10-12.03","DOIUrl":"https://doi.org/10.33224/rrch.2022.67.10-12.03","url":null,"abstract":"Amygdalin (AMG) is mainly as an alternative therapy for traditional cancer treatment. In this study, an effective HPLC-DAD method was developed to investigate the extraction efficiency and determine AMG levels in fifteen fruit kernels belonging to different families. AMG in bitter almond was extracted from using various solvents by different extraction methods (Soxhlet, ultrasonic, orbital shaking and microwave extraction). The most suitable method was determined by the optimized HPLC-DAD method was applied to fifteen different fruit kernels. The recoveries were in the range 94.68% to 95.26%. The LOD and LOQ values were 0.0097 mg/g and 0.0295 mg/g, respectively. The amygdalin content in kernel fruits was determined ranging from 0.074 to 65.21 mg/g. This study showed that AMG was determined in a short time and with high yield, and the presence of AMG was proven in other fruit kernels belonging to different families that had not been proven before.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR, 13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.
{"title":"Synthesis and antimicrobially activities of coumarin-3-carboxamide derivatives","authors":"Hülya ÇELIK-ONAR, Gökçe BAYRAMOĞLU, Emel MATARACI-KARA","doi":"10.33224/rrch.2023.68.1-2.08","DOIUrl":"https://doi.org/10.33224/rrch.2023.68.1-2.08","url":null,"abstract":"In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR, 13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135594854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-17DOI: 10.33224/rrch.2023.68.1-2.09
Francisc POTMISCHIL, Mihaela HILLEBRAND
One of the most intensely studied features in the chemistry of nitrosamines is the restricted rotation around the N-N bond and, consequently, the estimation of the energy strain (Estr) determined by the NO group. This is rationalized in terms of the interaction between the electron lone-pairs of the amine nitrogen and the 𝜋 electrons of the –N=O group (nN-πNO* conjugation). Combining the results of DFT calculations on 43 nitrosamines (11 acyclic, 20 mono- and bicyclic and 12 tricyclic) with a multiple linear regression analysis, the paper affords a number of additive increments, which, by appropriate summation, are able to predict with a good accuracy the total energy of the nitroso compound (E) and the energy strain (Estr) values of the –N=O group for any acyclic or cyclic saturated nitrosamines.
在亚硝胺的化学性质中，研究最深入的特征之一是围绕N-N键的受限旋转，因此，由NO基团决定的能量应变(Estr)的估计。这是由胺态氮的电子孤对与-N =O基团(n -πNO*共轭)的相互作用来证明的。结合43种亚硝胺(11种无环，20种单环和双环，12种三环)的DFT计算结果和多元线性回归分析，本文给出了一些加性增量，通过适当的求和，可以较准确地预测任何无环或环饱和亚硝胺的- n =O基团的总能量(E)和能量应变(Estr)值。
{"title":"A computational study of the steric strain of –N=O groups in saturated nitrosamines","authors":"Francisc POTMISCHIL, Mihaela HILLEBRAND","doi":"10.33224/rrch.2023.68.1-2.09","DOIUrl":"https://doi.org/10.33224/rrch.2023.68.1-2.09","url":null,"abstract":"One of the most intensely studied features in the chemistry of nitrosamines is the restricted rotation around the N-N bond and, consequently, the estimation of the energy strain (Estr) determined by the NO group. This is rationalized in terms of the interaction between the electron lone-pairs of the amine nitrogen and the 𝜋 electrons of the –N=O group (nN-πNO* conjugation). Combining the results of DFT calculations on 43 nitrosamines (11 acyclic, 20 mono- and bicyclic and 12 tricyclic) with a multiple linear regression analysis, the paper affords a number of additive increments, which, by appropriate summation, are able to predict with a good accuracy the total energy of the nitroso compound (E) and the energy strain (Estr) values of the –N=O group for any acyclic or cyclic saturated nitrosamines.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135594857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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