猪瘟病毒候选疫苗筛选的初步研究

IF 0.2 4区农林科学 Q4 AGRICULTURE, DAIRY & ANIMAL SCIENCE Indian Journal of Animal Sciences Pub Date : 2023-10-06 DOI:10.56093/ijans.v93i10.125817

A RAMESH, K KUMANAN

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引用次数: 0

摘要

猪瘟在印度是一种具有重要经济意义的地方性猪瘟。虽然接种疫苗是控制该病的最佳方法，但目前可用的疫苗不是很有效。细胞培养适应当地病毒病原体菌株可能是大规模疫苗生产和更好的免疫力的更好选择。两株本地分离株和一株经典猪瘟病毒被适应于PK-15细胞，并评估了它们作为候选疫苗的适用性。CSFV分离株CSFV- ind - tn / Veng-09-020-Vn在连续传代40次后TCID50滴度为9.5，具有较好的血清转化效果，对CSFV强毒攻击具有较好的保护作用，可能是较好的候选疫苗菌株。

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Preliminary studies on selection of a vaccine candidate of Classical Swine Fever Virus

Classical swine fever is an economically important and endemic disease of swine in India. Though vaccination is the best way of controlling the disease, currently available vaccines are not very effective. Cell culture adapted local strains of viral pathogens could be a better choice for large scale vaccine production and better immunity. Two local isolates and one lapinized strain of Classical swine fever virus were adapted to PK-15 cells and assessed for their suitability as a vaccine candidate. The CSFV isolate, CSFV-Ind-TN/Veng-09-020–Vn, with a TCID50 titre of 9.5 after 40 continuous passages was found to give better seroconversion, good protection against virulent CSFV challenge and could be a better candidate vaccine strain.

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来源期刊

Indian Journal of Animal Sciences 农林科学-奶制品与动物科学

CiteScore

0.60

自引率

25.00%

发文量

220

审稿时长

8 months

期刊介绍： Articles published in The Indian Journal of Animal Sciences encompass a broad range of research topics in animal health and production related to cattle, buffalo, sheep, goat, camel, equines, pig, rabbit, yak, mithun, poultry and fisheries. Studies involving wildlife species and laboratory animal species that address fundamental questions about their biology will also be considered for publication. All manuscripts must present some new development and must be original, timely, significant and scientifically excellent. Papers will be rejected if standards of care of, or procedures performed on animals are not up to those expected of humane veterinary scientists. At a minimum, standards must meet the International Guiding Principles for Biomedical Research involving Animals, as issued by the Council for International Organizations of Medical Sciences. (C.I.O.M.S., c/o WHO, CH 1211 Geneva 27, Switzerland). Articles reporting new animal disease must follow GOI directive as given in detail in Guidelines to Authors.