环境中的邻苯二甲酸盐:它们的毒理学和对人类的相关风险

Paweł Wowkonowicz
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摘要

摘要本文综述了邻苯二甲酸二酯(PAEs)在各种产品和环境元素中的存在,以及它们的毒理学和可能的风险。PAEs已在各种环境元素中被检测到,包括空气、土壤、沉积物和垃圾填埋场渗滤液,以及地面、地表水和饮用水,这使其成为一种常见的环境污染物。在所有环境元素中最常见和可检测的邻苯二甲酸二(2-乙基己基)邻苯二甲酸酯(DEHP)。加起来,人类接触所有来源的邻苯二甲酸盐的量可能很大,对人类和其他生物构成同样严重的健康风险。一些PAEs,包括DEHP,邻苯二甲酸二正丁酯(DBP),邻苯二甲酸二异丁酯(DIBP)和邻苯二甲酸丁苄酯(BBP)被归类为生殖毒性和具有内分泌干扰特性。尽管世界各地对多环芳烃采取了严格的法规和限制,但仍需要对人类接触情况进行长期监测,以减少对人类和其他生物的潜在风险。
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Phthalates in the environment: Their toxicology and associated risk to humans
Abstract This review describes the presence of phthalate diesters (PAEs) in various products and elements of the environment, their toxicology, and possible risk is presented as reported in the scientific literature. PAEs have been detected in a variety of environmental elements, including air, soils, sediments, and landfill leachate, as well as in ground, surface, and drinking water, which makes them a common environmental contaminant. The most common and detectable phthalate in all elements of the environment is di(2-ethylhexyl) phthalate (DEHP). When added up, the amounts of human exposure to all sources of phthalates can be significant and pose an equally significant health risk to humans and other living organisms. Several PAEs, including DEHP, di-n-butyl phthalate (DBP), di-isobutylphthalate (DIBP), and butyl benzyl phthalate (BBP) are classified as toxic to reproduction and have endocrine-disrupting properties. Despite the introduction of strict regulations and restrictions on PAEs worldwide, long-term monitoring of human exposure is needed to reduce the potential risk to humans and other living organisms.
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