酪氨酸激酶抑制剂抗肿瘤治疗和心房颤动:对线粒体功能和心脏底物利用的潜在脱靶效应

IF 0.9 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Innovations and Applications Pub Date : 2023-01-01 DOI:10.15212/cvia.2023.0070
Yukun Li, Xiaodong Peng, Rong Lin, Xuesi Wang, Xinmeng Liu, Fanchao Meng, Yanfei Ruan, Rong Bai, Ribo Tang, Nian Liu
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引用次数: 0

摘要

酪氨酸激酶抑制剂(TKIs)是一类新型的抗肿瘤药物,在延长患者生存期方面具有显著的疗效。然而,TKIs的临床应用一直受到心房颤动(AF)主要不良反应的阻碍。最近的研究表明,TKIs诱导心肌细胞的代谢改变和重塑,从而扰乱能量代谢。具体来说,线粒体功能障碍和心脏底物利用的变化与tki诱导AF的机制有关。鉴于这些发现,本文回顾了tki诱导AF中涉及的能量代谢相关途径,确定了精确的治疗靶点,并讨论了可能有助于开发无心脏不良反应的新型tki的证据。
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Tyrosine Kinase Inhibitor Antitumor Therapy and Atrial Fibrillation: Potential Off-Target Effects on Mitochondrial Function and Cardiac Substrate Utilization
Tyrosine kinase inhibitors (TKIs) are a novel category of antitumor agents with remarkable efficacy in extending patient survival. However, clinical use of TKIs has been hindered by the major adverse effect of atrial fibrillation (AF). Recent studies have revealed that TKIs induce metabolic alterations and remodeling in cardiomyocytes, thus perturbing energy metabolism. Specifically, mitochondrial dysfunction and shifts in cardiac substrate utilization have been implicated in the mechanisms underlying TKI-induced AF. In light of these findings, this article reviews the energy metabolism-associated pathways involved in TKI-induced AF, identifies precise therapeutic targets for managing this condition, and discusses evidence that may contribute to the development of novel TKIs without cardiac adverse effects.
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来源期刊
Cardiovascular Innovations and Applications
Cardiovascular Innovations and Applications CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
0.80
自引率
20.00%
发文量
222
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