FZR1在肿瘤发生中的作用:关注细胞周期控制

Pub Date : 2023-01-01 DOI:10.32604/biocell.2023.029373

HUI LI, CHENGFANG ZHOU, MEI KUANG, YUN LIU, JIEPING CHEN

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引用次数: 0

摘要

fizzy相关蛋白同源物1 (FZR1)在细胞周期中主要作为后期促进复合物/环体(APC/C)的特异性激活因子，控制细胞周期的G0和G1期。我们重点介绍了FZR1通过细胞周期控制在肿瘤发生、生长、分化和基因组稳定性中的作用。我们总结了目前关于FZR1结构、功能以及APC/C失调在实体瘤和血液恶性肿瘤中的不同途径的知识现状。我们还讨论了靶向FZR1作为癌症治疗和未来工作研究领域的新方法。

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The role of FZR1 in tumorigenesis: Focus on cell-cycle control

Fizzy-related protein homolog 1 (FZR1) mainly functions as a specific activator of the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and controls the G0 and G1 phases of the cell cycle. We highlight recent work that has studied the role of FZR1 in tumorigenesis, growth, differentiation, and genome stability through cell-cycle control. We summarize the current state of knowledge regarding FZR1 structure, function, and the distinct ways of APC/C dysregulation in solid tumors and hematologic malignancies. We also discuss novel approaches for targeting the FZR1 as a cancer therapy and research area for future work.

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