姜提取物软膏对未产妇女会阴切口疼痛和伤口愈合的影响:一项随机临床试验

Fatemeh Cheshfar, Soheila Bani, Mojgan Mirghafourvand, Shirin Hasanpour, Yousef Javadzadeh
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摘要

外阴切开术是一种常见的助产手术。伊朗是一个药用植物资源丰富的国家。本研究旨在探讨姜提取物软膏对未产妇女会阴切开术切口疼痛和恢复的影响。方法:本随机临床试验在伊朗某公立医院对70例未生育妇女行会阴切开手术。这些妇女被随机分配到生姜提取物软膏组和安慰剂组。主要结果包括疼痛和伤口愈合,使用视觉模拟量表(VAS)、红肿、水肿、瘀斑/瘀伤、出血和近似量表(REEDA)进行评估。在出院前以及干预后5×1和10×1天对参与者进行随访。次要结果是研究期间使用止痛药的数量。数据分析采用卡方检验、独立t检验和SPSS-13 Mann-Whitney U检验。以P≤0.05为显著性水平。结果:在干预前、干预后5×1和10×1天,生姜提取物软膏组和安慰剂组的疼痛和伤口愈合评分无显著差异。但临床疼痛强度降低,恢复速度加快。此外,关于本研究的次要结局,安慰剂组和干预组在参与者服用止痛药的数量上没有显著差异。结论:生姜软膏不能明显改善会阴切口创面的疼痛和愈合,但具有临床应用价值。因此,需要对这种软膏的不同剂量进行更多的研究。
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The Effects of Ginger (Zingiber officinale) Extract Ointment on Pain and Episiotomy Wound Healing in Nulliparous Women: A Randomized Clinical Trial
Introduction: Episiotomy is a usual midwifery surgery. Iran is a country with an abundant source of medicinal plants. This study aimed to investigate ginger extract ointment’s effects on the pain and recovery of episiotomy incisions in nulliparous women. Methods: This randomized clinical trial was conducted in a public hospital in Iran on 70 nulliparous women with an episiotomy incision. The women were randomly assigned to ginger extract ointment and placebo groups. The primary outcomes included pain and wound healing that were assessed using a visual analog scale (VAS), redness, edema, ecchymosis/bruising, discharge, and an approximation scale (REEDA). The participants were followed up before discharge from the hospital and 5×1 and 10×1 days after the intervention. The secondary outcome was the number of painkillers used during the study. Data were analyzed by chi-square, independent t test, and the Mann-Whitney U via SPSS-13. The significance levels were determined to be P≤0.05. Results: There was no significant difference between participants treated with ginger extract ointment and placebo in the pain and wound healing scores before the intervention, 5×1 and 10×1 days after the intervention. But, the pain intensity decreased, and the recovery speed increased clinically. Also, regarding the secondary outcome of this study, no significant difference between the placebo and intervention groups in the number of painkillers participants took. Conclusion: The ginger ointment could not significantly improve episiotomy wounds’ pain and healing rate, but it was clinically helpful. So more studies with different doses of this ointment are needed.
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