乳糜泻——一个全面的综述

IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Srpski arhiv za celokupno lekarstvo Pub Date : 2023-01-01 DOI:10.2298/sarh230716098r
Nedeljko Radlovic, Zoran Lekovic, Marija Mladenovic, Biljana Vuletic, Jelena Radlovic, Sinisa Ducic, Dejan Nikolic
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引用次数: 0

摘要

乳糜泻是由小麦、黑麦和大麦中的谷蛋白引起的多系统自身免疫性疾病。它的特点是多基因易感性,在白人人群中普遍存在(1%),特别是在近亲中(5-15%),表达非常异质,经常与其他自身免疫性疾病相关(3-10%),以及IgA和唐氏、特纳和威廉姆斯综合征的选择性缺乏。该疾病的基础和诊断的关键发现是麸质敏感性肠病,即小肠黏膜的非特异性炎症,可通过无麸质饮食解决。除了肠病,无论是有症状还是无症状,该病还以各种肠外表现为特征,甚至出现非常严重的并发症。治疗是基于终身无麸质饮食,因此,如果及时诊断和持续治疗,这种疾病有很好的预后。
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Celiac disease - a comprehensive review
Celiac disease is a multisystemic autoimmune disease induced by gluten in wheat, rye and barley. It is characterized by polygenic predisposition, prevailing prevalence in members of the white population (1%), especially in close relatives (5-15%), very heterogeneous expression and frequent association with other autoimmune diseases (3-10%), as well as selective deficiency of IgA and Down, Turner and Williams syndromes. The basis of the disease and the key finding in its diagnostics is gluten-sensitive enteropathy, i.e., non-specific inflammation of the small intestinal mucosa which resolves by gluten-free diet. In addition to enteropathy, whether symptomatic or asymptomatic, the disease is also characterized by various extraintestinal manifestations, and even very serious complications. Therapy is based on a lifelong gluten-free diet, so that the disorder, if diagnosed in time and treated consistently, has an excellent prognosis.
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来源期刊
Srpski arhiv za celokupno lekarstvo
Srpski arhiv za celokupno lekarstvo MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
50.00%
发文量
104
审稿时长
4-8 weeks
期刊介绍: Srpski Arhiv Za Celokupno Lekarstvo (Serbian Archives of Medicine) is the Journal of the Serbian Medical Society, founded in 1872, which publishes articles by the members of the Serbian Medical Society, subscribers, as well as members of other associations of medical and related fields. The Journal publishes: original articles, communications, case reports, review articles, current topics, articles of history of medicine, articles for practitioners, articles related to the language of medicine, articles on medical ethics (clinical ethics, publication ethics, regulatory standards in medicine), congress and scientific meeting reports, professional news, book reviews, texts for "In memory of...", i.e. In memoriam and Promemoria columns, as well as comments and letters to the Editorial Board. All manuscripts under consideration in the Serbian Archives of Medicine may not be offered or be under consideration for publication elsewhere. Articles must not have been published elsewhere (in part or in full).
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