Gas sensors based on nanoparticle-assembled interfaces and their application in breath detection of lung cancer

Exhaled breath detection is a noninvasive method to diagnose diseases and is promising in the early screening of lung cancer. However, gas biomarkers of lung cancer within the exhaled breath are various and low content, and the exhaled breath has complex composition and strong fluidity, which puts forward high requirements for the performance of gas sensors. Hence, Wang’s team proposes a strategy for gas sensors based on nanoparticle-assembled interfaces. From the perspective of gas-sensing dynamics of exhaled breath, the microstructure of the sensing interface is designed to enhance their capture and adsorption efficiency via regulating the mass transfer behaviors of gas molecules so as to design high-performance sensors. In addition, from the three levels of cell, organ, and living body, this review summarizes the research strategy and progress of gas biomarkers of lung cancer and comments on the clinical application value of gas biomarkers in the breath detection of lung cancer. Then, this review introduces gas sensors with market application prospects, which promotes the breath detection of lung cancer from theoretical research to clinical application. Finally, breath sensors for lung cancer and prospected in smart homes are summarized.