低剂量口服米诺地尔治疗脱发:综合综述

IF 1.4 Q3 DERMATOLOGY Skin Appendage Disorders Pub Date : 2023-09-27 DOI:10.1159/000531890
Aditya K. Gupta, Mesbah Talukder, Avner Shemar, Bianca Maria Piraccini, Antonella Tosti
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引用次数: 0

摘要

低剂量口服米诺地尔(LDOM)在治疗各种头发疾病(包括男性雄激素性脱发(AGA)和女性型脱发(FPHL))方面显示出良好的安全性和有效性;然而,它还没有获得FDA的批准。男性AGA的LDOM起始剂量通常为1-5毫克/天,这取决于医生的偏好和患者的病情。对于FPHL,为0.5-1毫克/天。最大剂量一般为5毫克/天。如果患者反应良好且无重大副作用,则可以逐渐增加剂量,因为LDOM的疗效似乎是剂量依赖性的。如果治疗效果满意,患者可以长期使用LDOM。LDOM常见的副作用是多毛和心血管症状。女性比男性更容易多毛。LDOM的副作用可分为(a)剂量依赖性a型副作用(多毛和心血管症状)和(b)特异性b型副作用(心包积液)。米诺地尔通过多种途径起作用。虽然米诺地尔的半衰期相对较短,约为4小时,但其降压作用可能持续约72小时。治疗脱发的有效方法有限。因此,LDOM可能是治疗包括AGA在内的一些头发疾病的有效疗法的重要补充。
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Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review
Low-dose oral minoxidil (LDOM) has demonstrated a promising safety and efficacy profile in the treatment of various hair disorders, including male androgenetic alopecia (AGA) and female-pattern hair loss (FPHL); however, it lacks FDA approval. The usual LDOM starting dose for male AGA is 1–5 mg/day, depending on physician preference and the patient’s condition. For FPHL, it is 0.5–1 mg/day. The maximum dose is generally 5 mg/day. If patients respond well without major side effects, the dose may be gradually increased since the LDOM’s efficacy appears to be dose-dependent. Patients may use LDOM long term if the treatment outcome is satisfactory. The common side effects of LDOM are hypertrichosis and cardiovascular symptoms. Females are more prone to hypertrichosis than males. The side effects of LDOM can be categorized as (a) dose-dependent type A side effects (hypertrichosis and cardiovascular symptoms) and (b) idiosyncratic type B side effects (pericardial effusion). Minoxidil acts via multiple pathways. Although minoxidil has a relatively short half-life of around 4 h, its hypotensive effect may last approximately 72 h. Effective treatments for alopecia are limited. Therefore, LDOM could be an important addition to the available therapies for managing some hair disorders, including AGA.
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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
69
期刊最新文献
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