{"title":"香豆素-3-羧酰胺衍生物的合成及抗菌活性研究","authors":"Hülya ÇELIK-ONAR, Gökçe BAYRAMOĞLU, Emel MATARACI-KARA","doi":"10.33224/rrch.2023.68.1-2.08","DOIUrl":null,"url":null,"abstract":"In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR, 13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.","PeriodicalId":21323,"journal":{"name":"Revue Roumaine De Chimie","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and antimicrobially activities of coumarin-3-carboxamide derivatives\",\"authors\":\"Hülya ÇELIK-ONAR, Gökçe BAYRAMOĞLU, Emel MATARACI-KARA\",\"doi\":\"10.33224/rrch.2023.68.1-2.08\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR, 13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.\",\"PeriodicalId\":21323,\"journal\":{\"name\":\"Revue Roumaine De Chimie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2023-01-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revue Roumaine De Chimie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33224/rrch.2023.68.1-2.08\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue Roumaine De Chimie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33224/rrch.2023.68.1-2.08","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis and antimicrobially activities of coumarin-3-carboxamide derivatives
In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR, 13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.
期刊介绍：
The journal Revue Roumaine de Chimie (Roumanian Journal of Chemistry) was founded in 1956 under the name Revue de Chimie. Acad. R. P. R. from 1964, the title was modified in Revue Roumaine de Chimie (preserving the numbering of the volumes started in 1956). In 1997, the English translation of the title – Roumanian Journal of Chemistry – was also included on each issue.
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