神经内分泌肿瘤的治疗与精准医学

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI:10.5937/afmnai40-40887
Filip Veličković, Marina Vlajković, Miloš Stević, Nina Topić, Tamara Anđelković, Đuro Macut
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引用次数: 0

摘要

介绍。神经内分泌肿瘤(NETs)具有生长抑素受体(SSTR)表达增高,其中亚型2和亚型5最为常见。SSTR的过表达是不可手术性和转移性NETs的一个突出的分子靶标,它使靶向诊断和治疗成为一种独特的方法。除了sstr外,神经内分泌肿瘤还表达其他受体,这些受体可以成为核医学方法可视化的合适靶点。的目标。这篇综述论文的重点是最常见的放射性药物及其分子靶点,目前使用的治疗方法在NETs。结果。在传统核医学中,最重要的诊断放射性药物是标记为111 In和99m Tc的生长抑素类似物(SSA),但99m Tc具有更好的物理特性和更好的性能,优于111 In。近年来,针对NETs的成像和治疗已经建立了高效的治疗对,NETs可以强结合SSTR。68ga标记的奥曲肽衍生物被推荐用于NENs的诊断和随访。68 Ga放射性药物的巨大优势是,相同的化合物可以用治疗性放射性核素90y和177lu标记。结论。肽受体放射性核素治疗是一种全身性分子靶向治疗,已被证明对晚期和不能手术的NETs患者的疾病控制和延长生存期是安全有效的。由于不良事件可以忽略不计,这种疗法是安全的,应适用于所有符合必要标准的患者,主要是生长抑素受体2型过度表达的患者。
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Theranostics and precision medicine In neuroendocrine tumors
Introduction. Neuroendocrine tumors (NETs) have increased expression of somatostatin receptors (SSTR), where subtype 2 and 5 are the most common. Overexpression of the SSTR is an outstanding molecular target for inoperable and metastatic NETs that enables a unique approach of targeted diagnosis and treatment. In addition to SSTRs, neuroendocrine tumors also express other receptors that can be suitable targets for visualization by nuclear medicine methods. Aim. This review paper is focused on the most common radiopharmaceuticals and their molecular targets that are used today based on theranostic approach in NETs. Results. In conventional nuclear medicine, the most important diagnostic radiopharmaceuticals are somatostatin analogs (SSA) labeled with 111 In and 99m Tc, however 99m Tc has advantages over 111 In based on better physical characteristics and better performance. In recent years, highly potent theranostic pairs have been created for the imaging and treatment of NETs, which can strongly bind SSTR. Derivatives of 68 Ga-labeled octreotide are recommended for diagnostics and follow-up of NENs. The great advantage of 68 Ga radiopharmaceuticals is that identical compounds can be labeled with therapeutic radionuclides 90 Y and 177 Lu. Conclusion. Peptide receptor radionuclide therapy is a systemic molecular target therapy that has proven to be safe and very effective in controlling the disease and prolonging the survival of patients with advanced and inoperable NETs. With a negligible number of adverse events, this therapy is safe and should be administered to all patients who meet the necessary criterias, primarily overexpression of the somatostatin receptor type 2.
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来源期刊
Acta Facultatis Medicae Naissensis
Acta Facultatis Medicae Naissensis MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
0.00%
发文量
13
审稿时长
12 weeks
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