使用口服补充剂和局部佐剂治疗异维甲酸相关副作用:叙述性回顾

IF 1.4 Q3 DERMATOLOGY Skin Appendage Disorders Pub Date : 2023-10-20 DOI:10.1159/000533963
Sophia Reyes-Hadsall, Teresa Ju, Jonette E. Keri
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引用次数: 0

摘要

痤疮是皮脂腺单位的慢性炎症性疾病,具有多因素的病因,是皮肤科医生和初级保健医生治疗的最常见的疾病之一。在广泛和不断发展的治疗领域,口服异维甲酸已被证明对治疗严重的顽固性痤疮有效。异维甲酸的一些副作用已被报道,包括实验室异常,粘膜皮肤和肌肉骨骼的影响,这可能会降低依从性和患者对治疗的满意度。在这篇叙述性综述中,我们的目的是回顾口服补充剂或局部辅助治疗在减轻异维甲酸相关的粘膜和肌肉骨骼副作用方面的有效性和安全性。口服补充剂包括omega-3脂肪酸、维生素E、叶酸和维生素B12、抗组胺药、-肉毒碱、生物素和联合口服补充剂。局部佐剂包括透明质酸、生物糖胶-2和甘油凝胶霜;一种不油腻、不生粉刺、无香味的保湿霜;dexpanthenol;三氯乙酸;还有一款组合面霜。大多数补充剂和局部佐剂都有足够的证据证明其有效性,没有报告的不良事件,表明具有足够的安全性。服用异维甲酸的患者可能受益于口服补充剂和局部佐剂,以减少主要是粘膜皮肤的副作用,增加对治疗的依从性,从而改善总体结果。
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Use of Oral Supplements and Topical Adjuvants for Isotretinoin-Associated Side Effects: A Narrative Review
Acne is a chronic inflammatory disease of the pilosebaceous unit with a multifactorial etiology and is one of the most common conditions treated by dermatologists and primary care physicians. Within an extensive and evolving treatment landscape, oral isotretinoin has demonstrated efficacy for treatment of severe, recalcitrant acne. Several side effects of isotretinoin have been reported, including laboratory abnormalities, mucocutaneous, and musculoskeletal effects, which may reduce compliance and patient satisfaction with treatment. In this narrative review, we aim to review the efficacy and safety profile of oral supplements or topical adjuvant therapies in mitigating isotretinoin-associated mucocutaneous and musculoskeletal side effects. Oral supplements reviewed include omega-3 fatty acids, vitamin E, folic acid and vitamin B12, antihistamines, l-carnitine, biotin, and combined oral supplements. Topical adjuvants include a hyaluronic acid, biosaccharide gum-2, and glycerine gel-cream; a nongreasy, noncomedogenic, fragrance-free moisturizing cream; dexpanthenol; trichloroacetic acid; and a combination cream. Most of the supplements and topical adjuvants demonstrated efficacy with an adequate level of supporting evidence and no reported adverse events, indicating an adequate safety profile. Patients on isotretinoin may benefit from using oral supplements and topical adjuvants to minimize primarily mucocutaneous side effects, increase adherence to treatment, and thereby improve overall outcomes.
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CiteScore
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自引率
10.00%
发文量
69
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