前庭偏头痛及其管理在印度临床设置:叙述性回顾

Ilambarathi M., Avinash Bijlani, Dhrubo Roy
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摘要

前庭偏头痛(VM)是一种结合偏头痛和眩晕两种临床症状的疾病。据报道,患有头晕的印度人中VM的患病率很高(约30%)。然而,没有诊断和治疗的黄金标准。专门针对VM患者的试验很少。本文综述了在印度临床环境下VM及其管理的概况。专家小组成员对VM的文献进行了循证讨论和回顾,并收集了意见。专家认为,在眩晕诊所中,约50%的患者被诊断为VM,其中30-50岁的女性居多,而在儿童中,表现年龄为12-14岁。成人VM最常见的症状是自发性眩晕,其次是体位性眩晕,伴有头痛、恶心、呕吐、畏光和电话恐惧症,而对大声声音不耐受和突然跌倒是VM儿童的常见症状。与VM相关的常见合并症是良性阵发性位置性眩晕(BPPV)和梅尼埃病(MD)。专家认为,目前尚无批准的标准化治疗方案。VM管理的步骤包括饮食和生活方式的改变,以及用于缓解症状(流产)和预防和前庭康复的药物。在全球范围内,前庭抑制剂丙氯哌嗪被广泛用于眩晕及其相关症状的治疗。专家认为,丙氯哌嗪5毫克,每天2次或3次,连续5-7天,可作为一种流产治疗在各种VM患者的管理中发挥重要作用。
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Vestibular migraine and its management in Indian clinical setting: a narrative review
Vestibular migraine (VM) is a disorder connecting two clinical conditions, migraine and vertigo. A high prevalence of VM (~30%) is reported among Indians suffering from dizziness. Yet, there is no gold standard for diagnosis and treatment. Trials specifically for patients with VM are scarce. This review provides an overview on VM and its management in the Indian clinical setting. An evidence-based discussion and review of literature on VM was performed by expert panelists, and opinions were gathered. Experts opined that in vertigo clinics, around 50% of patients are diagnosed with VM, with a higher predominance in females aged 30-50 years, while in children, the age of manifestation is 12-14 years. The most common presenting symptoms of VM among adults are spontaneous vertigo, followed by positional vertigo with headache, nausea, vomiting, photophobia and phonophobia, while intolerance to loud sounds and sudden falls are common symptoms in children with VM. Common comorbidities associated with VM are benign paroxysmal positional vertigo (BPPV) and Meniere’s disease (MD). Experts opined that there are currently no approved standardized treatment protocols for VM. The steps in the management of VM include diet and lifestyle modification, along with medicines for symptomatic relief (abortive) and prophylaxis and vestibular rehabilitation. Globally, prochlorperazine, a vestibular suppressant, is widely used for the management of vertigo and its associated symptoms. According to experts, prochlorperazine 5 mg twice or thrice daily for 5-7 days can play a significant role as an abortive treatment in the management of various patient profiles of VM.
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