sm2促进2-硝基苯乙酸还原合成氧吲哚

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC Synthesis-Stuttgart Pub Date : 2023-09-13 DOI:10.1055/a-2175-1008

Pengkai Wang, Songlin Zhang

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引用次数: 0

摘要

本文首次报道了sm2促进2-硝基苯基乙酸还原为吲哚的反应。这个反应涉及到硝基的还原，通过N-O键的裂解和与邻近的羧基的直接缩合进行。从合成的角度出发，提出了一种在温和中性条件下合成吲哚的新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of Oxindoles via SmI2-Promoted Reduction of 2-Nitrophenylacetic Acids

The reduction of 2-nitrophenylacetic acid to oxindoles promoted by SmI2 is reported for the first time. This reaction involving the reduction of nitro group proceeds through N-O bond cleavage and direct condensation with the neighboring carboxyl group. From a synthetic point of view, a new method for the synthesis of oxindoles in mild neutral conditions is developed.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.