低剂量γ辐射场降低细胞活力，损伤DNA，增加人白细胞Hsp70和p53蛋白的表达

World Journal of Nuclear Science and Technology Pub Date : 2023-01-01 DOI:10.4236/wjnst.2023.134005

Jessica Lizbeth Sifuentes Padilla, David Alejandro García López, Consuelo Letechipia de León, Hector Rene Vega-Carrillo, Sergio Hugo Sánchez Rodríguez

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引用次数: 0

摘要

电离辐射是诊断和治疗疾病的工具。暴露于电离辐射导致白细胞减少已有报道。由于它们的放射敏感性，白细胞是分析细胞损伤的生物学模型。因此，我们评估了暴露于137Cs源低剂量伽马辐射场的人白细胞的细胞活力、DNA损伤和Hsp70和p53表达。细胞活力下降、DNA损伤、Hsp70和p53表达增加与辐照剂量成正比，辐照剂量分别为0.2、0.4、0.6、0.8和1.0 mGy。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Low-Dose Gamma Radiation Fields Decrease Cell Viability, Damage DNA, and Increase the Expression of Hsp70 and p53 Proteins in Human Leukocytes

Ionizing radiations are tools in diagnosis and treatment of diseases. Leukopenia from exposure to ionizing radiation has been reported. Due to their radiosensitivity, leukocytes are a biological model to analyze cell damage. Therefore, cell viability, DNA damage, and Hsp70 and p53 expression in human leukocytes exposed to low-dose gamma radiation fields from a 137Cs source were evaluated. A decrease in cell viability, DNA damage and an increase in the expression of Hsp70 and p53 proportional to the radiation dose received was found, which was 0.2, 0.4, 0.6, 0.8 and 1.0 mGy.

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