新型喹啉类杀虫剂氟美托昆的发现

IF 1.5 4区 农林科学 Q2 ENTOMOLOGY Journal of Pesticide Science Pub Date : 2023-01-01 DOI:10.1584/jpestics.d23-035
Takeru Kobayashi, Hiroki Hotta, Takaaki Miyake, Masahiro Nomura, Ryo Horikoshi, Kazumi Yamamoto
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引用次数: 0

摘要

Flometoquin, 2-乙基-3,7-二甲基-6-[4-(三氟甲氧基)苯氧基]喹啉-4-基碳酸甲酯是一种结构独特的新型杀虫剂。它是由日本Kayaku和Meiji Seika Kaisha株式会社(现为三井化学作物与生命解决方案株式会社)于2004年共同研究发现的。该化合物通过接触和取食对多种蓟马若虫期和成虫期具有强效、快速的杀虫作用,可最大限度地减少害虫对作物的危害和经济损失。此外,氟米托昆对非靶节肢动物是安全的,这使得它适用于害虫综合管理(IPM)项目中上述害虫的控制。在这里,我们描述了一个结构-活性关系的研究,从铅的产生到发现氟美托昆及其杀虫特性,包括敲除活性和对非靶向节肢动物的作用。
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Discovery of flometoquin, a novel quinoline insecticide
Flometoquin, 2-ethyl-3,7-dimethyl-6-[4-(trifluoromethoxy)phenoxy]quinolin-4-yl methyl carbonate, is a novel insecticide with a structurally unique phenoxy-quinoline. It was discovered in 2004 by the collaborative research of Nippon Kayaku and Meiji Seika Kaisha, Ltd. (currently, Mitsui Chemicals Crop & Life Solutions, Inc.). The compound demonstrates strong and quick insecticidal action against a variety of thrips species at the nymphal and adult stages through contact and feeding activity, which could minimize crop damage and economic loss by insect pest species. In addition, flometoquin is safe for tested non-target arthropods, which makes it suitable for controlling the insect pests mentioned above under Integrated Pest Management (IPM) programs. Here, we describe a structure–activity relationship study from lead generation to the discovery of flometoquin and its insecticidal properties, including knockdown activity and effects against non-targeted arthropods.
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来源期刊
Journal of Pesticide Science
Journal of Pesticide Science 农林科学-昆虫学
CiteScore
4.30
自引率
4.20%
发文量
28
审稿时长
18-36 weeks
期刊介绍: The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.
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