{"title":"心血管衰老过程中的肾上腺素能信号传导","authors":"Ioannis D Kyriazis , Claudio de Lucia","doi":"10.1016/j.cophys.2023.100722","DOIUrl":null,"url":null,"abstract":"<div><p><span>The average lifespan of humans is increasing worldwide, and the percentage of older adults is substantially growing. The adrenergic system is a crucial determinant for the cardiovascular homeostasis during aging. In this short review, we discuss the new insights that emerged concerning the role of </span>adrenergic receptors<span> and relative signaling in the aging of the heart and vasculature with particular emphasis on molecular mechanisms involved. We also examine specific therapeutic interventions that modulate the adrenergic system feasibly counteracting and delaying age-induced pathophysiological changes in cardiovascular function and structure.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adrenergic signaling in cardiovascular aging\",\"authors\":\"Ioannis D Kyriazis , Claudio de Lucia\",\"doi\":\"10.1016/j.cophys.2023.100722\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>The average lifespan of humans is increasing worldwide, and the percentage of older adults is substantially growing. The adrenergic system is a crucial determinant for the cardiovascular homeostasis during aging. In this short review, we discuss the new insights that emerged concerning the role of </span>adrenergic receptors<span> and relative signaling in the aging of the heart and vasculature with particular emphasis on molecular mechanisms involved. We also examine specific therapeutic interventions that modulate the adrenergic system feasibly counteracting and delaying age-induced pathophysiological changes in cardiovascular function and structure.</span></p></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468867323000937\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867323000937","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
The average lifespan of humans is increasing worldwide, and the percentage of older adults is substantially growing. The adrenergic system is a crucial determinant for the cardiovascular homeostasis during aging. In this short review, we discuss the new insights that emerged concerning the role of adrenergic receptors and relative signaling in the aging of the heart and vasculature with particular emphasis on molecular mechanisms involved. We also examine specific therapeutic interventions that modulate the adrenergic system feasibly counteracting and delaying age-induced pathophysiological changes in cardiovascular function and structure.
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