回应文章;唾液IgA作为头颈癌术后接受放化疗患者微生物感染的替代生物标志物。中华检验医学杂志,2009;15(2):264-268。

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Journal of Laboratory Physicians Pub Date : 2023-09-25 DOI:10.1055/s-0043-1775763
Erkan Topkan, Efsun Somay, Uğur Selek
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引用次数: 0

摘要

我们祝贺Chavan等人的研究,该研究探讨了唾液免疫球蛋白A (IgA)s水平在预测接受辅助放化疗(CRT)的头颈癌(HNC)患者微生物感染中的意义。[1]他们的研究结果表明,在crt后患者中,细菌感染的患病率显著上升,主要是肺炎克雷伯菌和铜绿假单胞菌。此外,获得细菌和真菌感染的口腔黏膜炎患者的唾液IgA水平显著高于未感染的患者(p = 0.003)。本研究的结果为辐射毒性与粘膜免疫反应之间的关系提供了有价值的见解,特别是在口腔黏膜炎和伴随感染的背景下。然而,有两个问题需要进一步讨论,这可能有助于对这个热门话题的现有知识体系。
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In response to the article; “Salivary IgA as a Surrogate Biomarker for Microbial Infections in Postoperative Patients Receiving Chemo-Radio-Therapy for Head and Neck Cancer. J Lab Physicians. 2023;15(2):264-268”
We congratulate Chavan et al for their study that explored the significance of salivary immunoglobulin A (IgA)s levels in predicting microbial infections in patients with head and neck cancer (HNC) who underwent adjuvant chemoradiotherapy (CRT).[1] Their findings demonstrated a considerable rise in the prevalence of bacterial infections, mostly Klebsiella pneumoniae and Pseudomonas aeruginosa, in post-CRT patients. Furthermore, individuals with oral mucositis who acquired bacterial and fungal infections had significantly higher levels of salivary IgA (p = 0.003) than those who did not. The results of this study provide valuable insights into the relationship between radiation-induced toxicities and the mucosal immune response, specifically in the context of oral mucositis and concomitant infections. However, two issues need further discussion, which may contribute to the existing body of knowledge on this hot topic.
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来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
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审稿时长
31 weeks
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