卵母细胞的低温保存:历史、成就与未来

Shiyu Zhao, Gang Zhao
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引用次数: 0

摘要

近年来,由于肿瘤和非肿瘤的原因,对女性生育能力保存的要求越来越高,满足这些需求将是未来几年的一个热门话题。卵母细胞冷冻保存是保存妇女生育能力的可行选择,在哺乳动物基因库和人类卵母细胞库方面已经取得了很大进展。本文系统地介绍了卵母细胞冷冻和玻璃化技术的发展历史,重点介绍了玻璃化载体。此外,我们还概述了卵母细胞玻璃化的基本原理,并讨论了玻璃化对卵母细胞质量的影响。提出了提高卵母细胞低温保存效果的对策。最后,对卵母细胞低温保存技术进行了总结,并对其发展前景进行了展望。
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Cryopreservation of oocytes: history, achievements and future
There have been increasing requirements for women’s fertility preservation due to oncological and nononcological reasons in recent years, and meeting these demands will be a hot topic in the coming years. Oocyte cryopreservation is a workable option for preserving women’s fertility, and great advances have already been made and much progress has been made in mammalian gene banking and human oocyte banks. In this paper, we systematically introduce the history of oocyte cryopreservation and vitrification technology and highlight the vitrification carrier. Furthermore, we summarize the fundamentals of oocyte vitrification and discuss the effects of vitrification on oocyte quality. Strategies to improve the effect of oocyte cryopreservation are also proposed. At the end of this review, we conclude oocyte cryopreservation and outline future perspectives.
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