Judith Zubia-Aranburu, Lorea Buruaga, Myriam Martin-Inaraja, Clara Rodriguez, Silvia Santos, Unai Silván, Cristina Eguizabal, Alaitz Zabala
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The successful transferability of the patterns was quantified through height, hybrid and functional surface topography parameters. Additionally, ethylene oxide, hydrogen peroxide (H 2 O 2 ) and ultraviolet (UV) sterilisation methods were tested, of which only UV preserved the morphological and functional integrity of the mat. Finally, fibroblasts were used to analyse the cytotoxicity and cellular response of the dressings, verifying their biocompatible nature. This study demonstrates that absorption capacity can be modulated by the surface texture of the wound dressing. The S dq and S dr parameters were identified as key surface characteristics for enhancing absorption capacity and yielded an increase of up to 176.76% compared with the non-textured control, thus revealing the potential of surface functionalisation for increasing exudate absorption.","PeriodicalId":22032,"journal":{"name":"Surface Innovations","volume":"3 1","pages":"0"},"PeriodicalIF":2.7000,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Towards tailored surface topography on electrospun wound dressings for maximised exudate absorption\",\"authors\":\"Judith Zubia-Aranburu, Lorea Buruaga, Myriam Martin-Inaraja, Clara Rodriguez, Silvia Santos, Unai Silván, Cristina Eguizabal, Alaitz Zabala\",\"doi\":\"10.1680/jsuin.23.00044\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Since electrospinning can generate micro- to nanometre-scale fibres, it is widely used for fabricating wound dressings. Electrospun scaffolds with defined three-dimensional patterns at the mat surface can be efficiently fabricated using textured collectors that transfer the topography during the manufacturing process. However, the efficacy of surface pattern transfer from the collector to the mat, the correlation between the topography and the absorption capability and the effect of sterilisation on absorption have not yet been analysed. In this study, textured patterns were imprinted over polycaprolactone electrospun mats using textured collectors. The successful transferability of the patterns was quantified through height, hybrid and functional surface topography parameters. Additionally, ethylene oxide, hydrogen peroxide (H 2 O 2 ) and ultraviolet (UV) sterilisation methods were tested, of which only UV preserved the morphological and functional integrity of the mat. Finally, fibroblasts were used to analyse the cytotoxicity and cellular response of the dressings, verifying their biocompatible nature. This study demonstrates that absorption capacity can be modulated by the surface texture of the wound dressing. 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Towards tailored surface topography on electrospun wound dressings for maximised exudate absorption
Since electrospinning can generate micro- to nanometre-scale fibres, it is widely used for fabricating wound dressings. Electrospun scaffolds with defined three-dimensional patterns at the mat surface can be efficiently fabricated using textured collectors that transfer the topography during the manufacturing process. However, the efficacy of surface pattern transfer from the collector to the mat, the correlation between the topography and the absorption capability and the effect of sterilisation on absorption have not yet been analysed. In this study, textured patterns were imprinted over polycaprolactone electrospun mats using textured collectors. The successful transferability of the patterns was quantified through height, hybrid and functional surface topography parameters. Additionally, ethylene oxide, hydrogen peroxide (H 2 O 2 ) and ultraviolet (UV) sterilisation methods were tested, of which only UV preserved the morphological and functional integrity of the mat. Finally, fibroblasts were used to analyse the cytotoxicity and cellular response of the dressings, verifying their biocompatible nature. This study demonstrates that absorption capacity can be modulated by the surface texture of the wound dressing. The S dq and S dr parameters were identified as key surface characteristics for enhancing absorption capacity and yielded an increase of up to 176.76% compared with the non-textured control, thus revealing the potential of surface functionalisation for increasing exudate absorption.
Surface InnovationsCHEMISTRY, PHYSICALMATERIALS SCIENCE, COAT-MATERIALS SCIENCE, COATINGS & FILMS
CiteScore
5.80
自引率
22.90%
发文量
66
期刊介绍:
The material innovations on surfaces, combined with understanding and manipulation of physics and chemistry of functional surfaces and coatings, have exploded in the past decade at an incredibly rapid pace.
Superhydrophobicity, superhydrophlicity, self-cleaning, self-healing, anti-fouling, anti-bacterial, etc., have become important fundamental topics of surface science research community driven by curiosity of physics, chemistry, and biology of interaction phenomenon at surfaces and their enormous potential in practical applications. Materials having controlled-functionality surfaces and coatings are important to the manufacturing of new products for environmental control, liquid manipulation, nanotechnological advances, biomedical engineering, pharmacy, biotechnology, and many others, and are part of the most promising technological innovations of the twenty-first century.