“DECAF评分”预测阿联酋慢性阻塞性肺病急性加重的疾病严重程度和住院死亡率的国际验证

IF 0.8 Q4 PHARMACOLOGY & PHARMACY Hospital Pharmacy Pub Date : 2023-11-03 DOI:10.1177/00185787231209218
Khadeijah Almarshoodi, Carlos Echevarria, Abeer Kassem, Bassam Mahboub, Laila Salameh, Chris Ward
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引用次数: 0

摘要

一些医院已采用DECAF评分(呼吸困难、红细胞减少、实变、学术界和心房颤动评分)来预测慢性阻塞性肺疾病急性加重期(AECOPD)的严重程度。然而,DECAF评分在中东国家尚未被广泛评估或使用。本研究旨在验证DECAF评分在预测阿拉伯联合酋长国AECOPD患者住院死亡率方面的作用。这是一项在阿联酋19家医院进行的回顾性观察性研究。数据从全国17家医院的AECOPD住院患者的电子记录中检索。年龄超过35岁的AECOPD患者被纳入研究。采用受试者操作曲线下面积(AUROC)对住院死亡、30天死亡和90天再入院患者的DECAF评分进行验证。住院死亡、30天死亡和90天再入院的AUROCDECAF曲线分别为0.8 (95% CI: 0.8-0.9)、0.8 (95% CI: 0.7-0.8)和0.8 (95% CI: 0.8-0.8)。模型与数据拟合满意(Hosmer-Lemeshow统计量= 0.195,Nagelkerke r2 = 31.7%)。不同DECAF评分患者的平均住院时间差异有统计学意义(P = 0.008)。DECAF评分为6的患者平均住院时间最长,为29.8±31.4天。DECAF评分为0的患者平均住院时间最短,为3.6±2.0天。DECAF评分是预测阿联酋医院住院患者死亡、30天死亡率和90天再入院的有力工具。DECAF评分是预测阿联酋AECOPD患者死亡率和其他疾病结局的有效工具;因此,临床医生将更有权通过使用DECAF评分做出适当的临床决策。
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An International Validation of the “DECAF Score” to Predict Disease Severity and Hospital Mortality in Acute Exacerbation of COPD in the UAE
The DECAF score (the Dyspnea, Eosinopenia, Consolidation, Academia, and Atrial fibrillation score) has been adopted in some hospitals to predict the severity of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). However, DECAF score has not been widely evaluated or used in Middle Eastern countries. The present study aimed to validate the DECAF score for predicting in-hospital mortality in patients with AECOPD in the United Arab Emirates (UAE). This was a retrospective, observational study conducted in 19 hospitals in the UAE. Data were retrieved from the electronic records of patients admitted for AECOPD in 17 hospitals across the country. Patients aged more than 35 years who were diagnosed with AECOPD were included in the study. The validation of the DECAF Score for inpatient death, 30-days death, and 90-day readmission was conducted using the Area Under the Receiver Operator curve (AUROC). The AUROCDECAF curves for inpatient death, 30-days death, and 90-day readmission were 0.8 (95% CI: 0.8-0.9), 0.8 (95% CI: 0.7-0.8), and 0.8 (95% CI: 0.8-0.8), respectively. The model was a satisfactory fit to the data (Hosmer–Lemeshow statistic = 0.195, Nagelkerke R 2 = 31.7%). There were significant differences in means of length of stay across patients with different DECAF score ( P = .008). Patients with a DECAF score of 6 had the highest mean length of stay, which was 29.8 ± 31.4 days. Patients with a DECAF score of 0 had the lowest mean length of stay, which was 3.6 ± 2.0 days. The DECAF score is a strong predictive tool for inpatient death, 30 days mortality and 90-day readmission in UAE hospital settings. The DECAF score is an effective tool for predicating mortality and other disease outcomes in patients with AECOPD in the UAE; hence, clinicians would be more empowered to make appropriate clinical decisions by using the DECAF score.
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来源期刊
Hospital Pharmacy
Hospital Pharmacy PHARMACOLOGY & PHARMACY-
CiteScore
1.70
自引率
0.00%
发文量
63
期刊介绍: Hospital Pharmacy is a monthly peer-reviewed journal that is read by pharmacists and other providers practicing in the inpatient and outpatient setting within hospitals, long-term care facilities, home care, and other health-system settings The Hospital Pharmacy Assistant Editor, Michael R. Cohen, RPh, MS, DSc, FASHP, is author of a Medication Error Report Analysis and founder of The Institute for Safe Medication Practices (ISMP), a nonprofit organization that provides education about adverse drug events and their prevention.
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