Bacteriophage therapy for Acinetobacter baumannii-induced superficial wounds in experimental mice.

Antibiotic resistance is one of the most greatest hazards to human health in the modern era. Incredibly even more concerning is how quickly antibiotic-resistant bacteria can spread throughout the global community and in healthcare settings. In this study, locally isolated bacteriophages with the ability to lyse multidrug-resistant bacteria were isolated from wastewater as one strategy to combat multidrug-resistant bacteria. Examination of phage morphology by electron microscope showed three-tailed phages related to three families, in which ФEEP belonged to the family Siphoviridae . ФEPP phage belonged to Podoviridae and ФEAP belonged to Myoviridae . The ФEAP was specific to acinetobacter baumannii subsequently was chosen to applied on our study. The therapeutic efficacy of ФEAP was evaluated in a mouse model of a complete wound that acquired an infection of A.baumannii . Phage-treated wounds inoculated with ФEAP demonstrated full regeneration; high-quality wound healing, and elimination of bacteria with infection. All of those characteristics combine to ФEAP phage a potential treatment for infections of skin wounds by MDR A.baumannii . Nevertheless, additional investigation and clinical research studies on the phage combinations that are needed to be applied topically in wound infections must be conducted.