自身免疫性脑炎的癫痫表现

S. K. Yevtushenko, Yu. N. Sorokin
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引用次数: 0

摘要

自身免疫性脑炎(AIE)的发展是由于对脑组织各种结构的细胞内和细胞外神经元抗体的形成。其流行率和发病率与传染病相当,近年来检出率不断上升。急性症状性癫痫发作是AIE临床核心的重要组成部分,与异质自身抗体群相关,其与病变部位的特征一起导致癫痫发作的临床多样性显著。脑电图具有发作期和间歇期的特征,也可能发生亚临床癫痫发作。AIE合并癫痫发作的治疗基础是免疫治疗,同时使用具有钠通道阻断特性的抗癫痫药物。
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Epileptic manifestations of autoimmune encephalitis
The development of autoimmune encephalitis (AIE) is due to the formation of intracellular and extracellular neuronal antibodies to various structures of the brain tissue. Their prevalence and morbidity are comparable to infectious ones, and the detection rate has recently been increasing. Acute symptomatic seizures are an important component of the clinical core of AIE and are associated with a heterogeneous group of autoantibodies, which along with the features of the lesion topic causes a signi fi cant clinical variety of seizures. The EEG has ictal and interictal features, and the development of electrographic subclinical seizures is also possible. The basis of the treatment of AIE with epileptic seizures is immunotherapy along with the use of antiepileptic drugs with sodium channel blocking properties.
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来源期刊
Russian Neurological Journal
Russian Neurological Journal Medicine-Neurology (clinical)
CiteScore
0.40
自引率
0.00%
发文量
49
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