纳米体作为靶向给药系统的研究进展

K Pooja, S B Shirsand
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引用次数: 0

摘要

由于缺乏有效的治疗因素或药物输送系统,许多疾病得不到治疗,特别是当副作用和毒性是主要引起关注的时候。因此,我们选择了新型给药系统。乳质体的结构由亲水、亲两、亲脂三大部分组成,可容纳多种溶解度较大的药物分子。乳质体比脂质体更受欢迎,因为与磷脂相比,乳质体的非离子表面活性剂具有更高的稳定性、更低的成本和更易于储存。表面活性剂不需要任何特殊的处理或储存条件。Niosomes是一种受控的靶向药物传递系统,可降低毒性并增加药物对靶组织的渗透。本文综述了乳质体制剂的优缺点、乳质体的特性及其应用。
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Advances of Niosomes as a Targeted Drug Delivery Syste
Due to a lack of effective treatment factor or drug delivery systems many diseases go untreated especially when side effects and toxicities are the main cause of concern. Consequently we chose novel drug delivery system. The structure of niosomes is made up of three moieties hydrophilic amphiphilic and lipophilic which can accommodate several drug molecules with a wide range of solubilities. Niosomes are preferred over liposomes because of the non-ionic surfactants higher stability lower cost and ease of storage compared to phospholipids. Surfactants do not require any particular handling or storage conditions. Niosomes act as a controlled and targeted drug delivery system that reduces toxicity and increases drug penetration into target tissues. The review article focused on several ideas including advantages and disadvantages of niosomal preparations niosome characteristics and its application.
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