Development of Dendrimer-5-Flurouracil and Folic acid Conjugation for the Treatment of Colon Cancer via Target Drug Delivery

Background Cancer cells are also known as carcinoma sarcoma melanoma lyphoma and leukemia. The ability of the bodys immune cells to recognise and eliminate newly formed cells when there arent many of them is probably more crucial to the development of cancer than the conversion of a normal cell into a malignant cell. Colonic epithelial cells which line the lumen of the organ and replace themselves every five days from a stem cell population found at the base of colonic epithelial cell crypts are the source of colon cancers.Aim To develop a Dendrimer of 5-Flurouracil and Folic acid conjugate for the treatment of colon cancer via target drug delivery.Methods The dendrimers of 5-Flurouracil and Folic acid conjugate were developed involving the following steps- formulation of dendrimer of antineoplastic drugs dendrimer Acylated Dendrimer characterization of compounds and in ndash vivo anti - cancer activity.Results On 7th and 14th a significant decrease in WBC increase in RBC and increase in Haemoglobin was observed compared to Cancer control.Conclusion It has been concluded that cancer induction in mice Groups I II III results in decreased RBC and Hb levels along with an increase in WBC count. Treatment with drugs restores the abnormal hematopoietic system parameters to normal levels in cancer-bearing mice.