驻极体阳性抑制金黄色葡萄球菌生物膜的机制

IF 3.8 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC IET Nanodielectrics Pub Date : 2023-10-31 DOI:10.1049/nde2.12065
Hongbao Wang, Hejuan Liang, Xin Guo, Jiajie Xu, Jian Jiang, Zhipeng Sun, Yuanyuan Liang
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引用次数: 0

摘要

细菌生物膜是细菌耐药的重要因素。近年来,驻极体膜对细菌生物膜的抑制作用已得到证实,其对生物膜的作用机制仍在进一步研究中。本工作以金黄色葡萄球菌为例,验证了正驻极体对细菌生物膜的抑制作用,并解释了其作用机制。有两个因素可以解释驻极体对细菌生物膜的抑制机制。一种可能是由于其抑制了正驻极体电场诱导的与细菌生物膜相关的关键基因的表达,另一种可能是阻止细菌聚集而不是直接的杀菌作用。这些结论有望推广到其他类型的细菌,并扩大静电材料在生物医学领域的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Mechanism of positive electret inhibition of Staphylococcus aureus biofilms

Bacterial biofilm is an important factor in bacterial drug resistance. Recently, it has been proved that electret films can inhibit the bacterial biofilm, while its mechanism of action on biofilms is under further investigation. In this work, taking Staphylococcus aureus as an example, the inhibition of positive electret on bacterial biofilm was verified and its mechanism was explained. Two factors have been found to explain the inhibition mechanism of electret on bacterial biofilms. One is probably due to its inhibition of the expression of key genes related to bacterial biofilms induced by the electric field of positive electret, and the other is to prevent the aggregation of bacteria rather than the direct bactericidal effect. The conclusions are expected to be extended to other types of bacteria and expand the application of electrostatic materials in the field of biomedicine.

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来源期刊
IET Nanodielectrics
IET Nanodielectrics Materials Science-Materials Chemistry
CiteScore
5.60
自引率
3.70%
发文量
7
审稿时长
21 weeks
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