有限承载能力群体中共同感染模型的随机分析

IF 2.4 3区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY International Journal of Biomathematics Pub Date : 2023-10-17 DOI:10.1142/s1793524523500833
Qura tul Ain, Jinrong Wang
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引用次数: 0

摘要

本文的重点是研究一个流行病模型的疾病演变,使用随机模型。我们演示了将这个复杂的模型编码为适合于使用高级随机模型检查器进行分析的形式。共同感染模型的动力学建模为伊藤-列维随机微分方程组,表示由疾病复杂性形成的室室系统。最初,我们建立了一个基于假设和疾病相关特征的确定性系统。通过非传统的分析方法,证明了两个关键的渐近性质:在平均值上的根除和连续。第2节提供了该模型的详细构造。第3节的结果证实,结果在生物学上表现良好。利用仿真,我们测试并确认了所有平衡点的稳定性。深入分析了系统的遍历平稳分布和消光条件。对随机系统的概率密度函数进行了研究,并采用数字仿真的方法对概率密度函数和系统消光进行了说明。虽然传染病控制和根除是主要的公共卫生目标,但全球根除证明具有挑战性。地方病有灭绝的可能,但也有复发的可能。在较低(公式:见文本)的情况下,灭绝更可行。值得注意的是,我们的模拟表明,降低[公式:见文本]值可显著增加疾病灭绝的可能性,并降低未来复发的概率。此外,我们的研究提供了对疾病持续存在或灭绝的条件的见解,有助于在公共卫生中制定更有效的疾病控制策略。
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A stochastic analysis of co-infection model in a finite carrying capacity population
The paper focuses on the study of an epidemic model for the evolution of diseases, using stochastic models. We demonstrated the encoding of this intricate model into formalisms suitable for analysis with advanced stochastic model checkers. A co-infection model’s dynamics were modeled as an Ito–Levy stochastic differential equations system, representing a compartmental system shaped by disease complexity. Initially, we established a deterministic system based on presumptions and disease-related traits. Through non-traditional analytical methods, two key asymptotic properties: eradication and continuation in the mean were demonstrated. Section 2 provides a detailed construction of the model. Section 3 results confirm that the outcome is biologically well-behaved. Utilizing simulations, we tested and confirmed the stability of all equilibrium points. The ergodic stationary distribution and extinction conditions of the system are thoroughly analyzed. Investigations were made into the stochastic system’s probability density function, and digital simulations were employed to illustrate the probability density function and systems’ extinction. Although infectious disease control and eradication are major public health goals, global eradication proves challenging. Local disease extinction is possible, but it may reoccur. Extinction is more feasible with a lower [Formula: see text]. Notably, our simulations showed that reducing the [Formula: see text] value significantly increases the likelihood of disease extinction and reduces the probability of future recurrence. Additionally, our study provides insights into the conditions under which a disease can persist or become extinct, contributing to more effective disease control strategies in public health.
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来源期刊
International Journal of Biomathematics
International Journal of Biomathematics MATHEMATICAL & COMPUTATIONAL BIOLOGY-
CiteScore
4.70
自引率
13.60%
发文量
820
审稿时长
7.5 months
期刊介绍: The goal of this journal is to present the latest achievements in biomathematics, facilitate international academic exchanges and promote the development of biomathematics. Its research fields include mathematical ecology, infectious disease dynamical system, biostatistics and bioinformatics. Only original papers will be considered. Submission of a manuscript indicates a tacit understanding that the paper is not actively under consideration for publication with other journals. As submission and reviewing processes are handled electronically whenever possible, the journal promises rapid publication of articles. The International Journal of Biomathematics is published bimonthly.
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