{"title":"抗癌药物甲磺酸埃瑞布林C14-C26片段的聚合合成方法","authors":"Srihari Pabbaraja, Rajesh Nasam","doi":"10.1055/a-2202-5597","DOIUrl":null,"url":null,"abstract":"The stereoselective synthesis of C14-C26 fragment of eribulin is reported in a convergent way by coupling of fragment C14-C19 with fragment C20-C26 that are accessible from commercially available raw materials crotonic acid and 1,4-butanediol. The key steps involved in this practical approach are Hosomi-Sakurai asymmetric alkylation, Maruoka allylation, Noyori reduction, silver catalyzed one pot rearrangement and intramolecular cyclization","PeriodicalId":49451,"journal":{"name":"Synthesis-Stuttgart","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A convergent approach for the synthesis of C14-C26 fragment of anti-cancer drug eribulin mesylate\",\"authors\":\"Srihari Pabbaraja, Rajesh Nasam\",\"doi\":\"10.1055/a-2202-5597\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The stereoselective synthesis of C14-C26 fragment of eribulin is reported in a convergent way by coupling of fragment C14-C19 with fragment C20-C26 that are accessible from commercially available raw materials crotonic acid and 1,4-butanediol. The key steps involved in this practical approach are Hosomi-Sakurai asymmetric alkylation, Maruoka allylation, Noyori reduction, silver catalyzed one pot rearrangement and intramolecular cyclization\",\"PeriodicalId\":49451,\"journal\":{\"name\":\"Synthesis-Stuttgart\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2023-11-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthesis-Stuttgart\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/a-2202-5597\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis-Stuttgart","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2202-5597","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
A convergent approach for the synthesis of C14-C26 fragment of anti-cancer drug eribulin mesylate
The stereoselective synthesis of C14-C26 fragment of eribulin is reported in a convergent way by coupling of fragment C14-C19 with fragment C20-C26 that are accessible from commercially available raw materials crotonic acid and 1,4-butanediol. The key steps involved in this practical approach are Hosomi-Sakurai asymmetric alkylation, Maruoka allylation, Noyori reduction, silver catalyzed one pot rearrangement and intramolecular cyclization
期刊介绍：
SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.
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