利用艾滋病毒分子流行病学方法确定地域流行病特征的相关性:俄罗斯库页岛地区

I. P. Osipova, A. V. Totmenin, P. G. Bersenev, E. Yu. Ilyina, E. A. Lomakina, N. M. Gashnikova
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引用次数: 0

摘要

的目标。目的:了解库页岛地区HIV感染地域分布的分子流行病学特征。材料与方法。对库页岛地区64名hiv感染居民的HIV-1分子遗传特征和临床流行病学资料进行了综合分析。通过对扩增的病毒片段测序,获得了编码HIV-1蛋白酶、逆转录酶和整合酶的pol基因区域的核苷酸序列。使用专门的软件资源进行基因分型、系统发育和突变分析。结果。在研究的HIV-1病例中,有81.3%的病例检测到HIV-1 A6亚型,其中58.4%的病例可靠地聚集在密切相关的HIV群体中,这表明感染传播的内部流行网络已经形成。此外,HIV-1 CRF63_02A6和06_cpx分别在4.7%的病例中检测到,B和B/G亚型占3.1%,C和A1亚型占1.6%。在MSM组中检测到HIV-1 A6、B/G变体和A1亚型与地中海HIV相似。在10.8%的病例中,未接受治疗的患者携带K103N突变的HIV-1,其中一例被鉴定出多重耐药。结论。目前,萨哈林地区境内艾滋病毒感染流行的特点是存在内部流行病网络以及输入性艾滋病毒的登记和传播。艾滋病毒感染的关键人群需要特别关注,因为有记录的耐抗逆转录病毒传播。研究俄罗斯个别地区艾滋病毒感染传播的特点,对于制定旨在结束该国艾滋病毒传播的有效措施非常重要。
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The relevance of using methods of molecular epidemiology of HIV to characterize territorial epidemics: Sakhalin region, Russia
Aim . To investigate the molecular-epidemiological characteristics of the territorial distribution of HIV infection in the Sakhalin region. Materials and Methods . A comprehensive analysis of molecular-genetic characteristics of HIV-1 and clinical-epidemiological data of 64 HIV-infected residents of the Sakhalin region was conducted. Nucleotide sequences of the pol gene region encoding protease, reverse transcriptase, and integrase of HIV-1 were obtained by sequencing amplified virus fragments. Genotyping, phylogenetic and mutational analyses were performed using specialized software resources. Results . Among the HIV-1 cases studied, the HIV-1 subtype A6 was detected in 81.3 % of cases, with 58.4 % of them reliably clustering into closely related HIV groups, indicating the development of internal epidemic networks of infection transmission. Additionally, HIV-1 CRF63_02A6 and 06_cpx were detected in 4.7 % of cases each, subtype B and B/G in 3.1 %, subtypes C and A1 in 1.6 %. HIV-1 A6, B/G variants, and subtype A1 similar to Mediterranean HIV were detected in the MSM group. In 10.8 % of cases, treatment-naive patients had HIV-1 with the K103N mutation, and in one case, multiple drug resistance was identified. Conclusion . The contemporary territorial epidemic of HIV infection in the Sakhalin region is characterised by the presence of internal epidemic networks and the registration and spread of imported HIV. Key population groups with HIV infection require special attention due to the documented transmission of ART-resistant viruses. Studying the peculiarities of HIV infection spread in individual regions of Russia is important for the development of effective measures aimed at ending HIV transmission in the country.
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来源期刊
CiteScore
0.80
自引率
50.00%
发文量
73
审稿时长
8 weeks
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