<i>Emblica officinalis</i> Gaertn. (<i>Amalaki</i>): A Natural Herbal Remedy to Enhance Cardiorespiratory Fitness in <i>Ayurveda</i> - An <i>In Silico</i> Molecular Docking Approach

Background: Cardiorespiratory fitness is the capacity of the circulatory and respiratory systems to transport oxygen to the skeletal muscle mitochondria for energy production during physical activity. Cardiorespiratory fitness has been recognized as a vital health biomarker and is very crucial for sports persons. Physical activities, aerobic exercise, yoga, meditation, nutritional supplements, and ergogenic aids are the ways to enhance cardiorespiratory fitness. Emblica officinalis Gaertn. is one of the widely used drugs in Ayurveda traditional medicine to enhance Cardiorespiratory Fitness (CRF). However, there is a dearth of clear information regarding how Emblica officinalis can improve CRF. Objective: The current in silico molecular docking study was planned to identify the phytochemicals, and targets of endurance and predict the probable mode of action of the drug and thereby substantiate the ability of Emblica officinalis as a natural and ethical way of enhancing cardiorespiratory fitness. Methods: The phytochemicals and targets are collected from reliable sources, and the effectiveness of these gene targets was validated using network pharmacology ligand-target interaction methods. The Protein Data Bank and PubChem were used to find the ligands and targets, and PyRx was used to do docking. Conclusion: Emblica officinalis is found to have a positive influence on the 12 metabolic pathways that act in enhancing the cardiorespiratory endurance in the human being. PRKCA was analyzed and concluded as the highly modulated gene target with the lowest binding energy. Thus, Emblica officinalis was found to have an action in enhancing cardio-respiratory endurance.