{"title":"四唑融合咪唑并吡啶的设计、合成和生物学研究","authors":"Banoth Reddy, Amit Kumar Taneja, Mandava Bhuvan Tej, Komati Navya Sri, Mandava Bhagya Tej, Suryadevara Vijayavardhini, Dandamudi Srilaxmi, Somasekhar Tiruveedhula, Srinivasa Rao Penumutchu, Mandava V. Basaveswara Rao","doi":"10.1007/s42823-023-00603-2","DOIUrl":null,"url":null,"abstract":"<div><p>New tetrazole fused imidazopyridine derivatives <b>(12a–j)</b> were developed to exploit their cytotoxic activity towards cancer cell lines-MCF7, A549, and MDA-MB-231, utilizing MTT reduction assay with doxorubicin as standard drug. The compounds <b>12 h</b> and <b>12j</b> demonstrated strong anticancer activity bearing IC<sub>50</sub> values 1.44 µM and 1.33 µM against A549 cell line.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":506,"journal":{"name":"Carbon Letters","volume":"34 1","pages":"41 - 49"},"PeriodicalIF":5.5000,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design, synthesis and biological studies of tetrazole fused imidazopyridines\",\"authors\":\"Banoth Reddy, Amit Kumar Taneja, Mandava Bhuvan Tej, Komati Navya Sri, Mandava Bhagya Tej, Suryadevara Vijayavardhini, Dandamudi Srilaxmi, Somasekhar Tiruveedhula, Srinivasa Rao Penumutchu, Mandava V. Basaveswara Rao\",\"doi\":\"10.1007/s42823-023-00603-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>New tetrazole fused imidazopyridine derivatives <b>(12a–j)</b> were developed to exploit their cytotoxic activity towards cancer cell lines-MCF7, A549, and MDA-MB-231, utilizing MTT reduction assay with doxorubicin as standard drug. The compounds <b>12 h</b> and <b>12j</b> demonstrated strong anticancer activity bearing IC<sub>50</sub> values 1.44 µM and 1.33 µM against A549 cell line.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><img></picture></div></div></figure></div></div>\",\"PeriodicalId\":506,\"journal\":{\"name\":\"Carbon Letters\",\"volume\":\"34 1\",\"pages\":\"41 - 49\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2023-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Carbon Letters\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s42823-023-00603-2\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbon Letters","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42823-023-00603-2","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Design, synthesis and biological studies of tetrazole fused imidazopyridines
New tetrazole fused imidazopyridine derivatives (12a–j) were developed to exploit their cytotoxic activity towards cancer cell lines-MCF7, A549, and MDA-MB-231, utilizing MTT reduction assay with doxorubicin as standard drug. The compounds 12 h and 12j demonstrated strong anticancer activity bearing IC50 values 1.44 µM and 1.33 µM against A549 cell line.
期刊介绍：
Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.
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