硫代氨基甲酸席夫碱配体及其与镍、钯和铂的配合物显示出抗癌和抗菌活性

IF 2.1 3区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Sulfur Chemistry Pub Date : 2024-01-01 DOI:10.1080/17415993.2023.2255711
Md. Azharul Arafath
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引用次数: 0

摘要

含有多齿席夫碱配体的硫代氨基甲酸噻吨在配位和生物应用领域备受关注。与游离配体相比,金属配合物具有更强的抗癌和抗菌活性,这是因为配合物具有更强的亲脂性。这些配体具有硬碱和软碱 S-N-O 配位位点,可同时与金属离子发生螯合作用。这些配体可通过各种模式与过渡金属配位。本文重点研究了硫代氨基甲酸席夫碱配体与镍、钯和铂金属离子的配位,以生成具有生物活性的配合物。配体和金属都具有很强的生物特性。因此,本研究考虑了最重要的生物活性,尤其是抗癌和抗菌活性。有关希夫碱配体及其过渡金属配合物的科学数据很多。不过,我们的研究收集了过去至今有关希夫碱硫代氨基甲酸配体及其配合物的更多信息数据。镍复合物对 Hela 癌细胞和 HCT 116 的活性高于顺铂,IC50 分别为 7.9 ± 0.2 µM 和 10.1 ± 0.09 µM。在不久的将来,这些类型的化合物可作为潜在的药剂用于治疗各种致命疾病。
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Thiosemicarbazone Schiff base ligands and their complexes with nickel, palladium and platinum show anticancer and antibacterial activities

The thiosemicarbazone containing polydentate Schiff base ligand is attracting interest in the field of coordination and biological application. The metal complexes exhibited stronger activity than free ligands against both cancer and bacteria due to the greater lipophilicity of complexes. These ligands possess hard and soft base S-N-O coordinating sites, which participate in chelation simultaneously with metal ions. These ligands could coordinate to transition metals through various modes. The paper focuses on the coordination of the thiosemicarbazone Schiff base ligands with nickel, palladium, and platinum metal ions to generate biologically active complexes. Both the ligands and the metals have strong biological properties. So, the most important biological activities, particularly anticancer and antibacterial are considered in the study. There is a lot of scientific data available regarding Schiff base ligands and their transition metal complexes. Still, our study collects more informative data, from the past to date, of Schiff base thiosemicarbazone ligands and their complexes. The nickel complex showed higher activity than cisplatin against Hela cancer cell, HCT 116 with IC50 of 7.9 ± 0.2 µM and 10.1 ± 0.09 µM respectively. These types of compounds could be used as potential medicinal agents in the near future against various lethal diseases.

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来源期刊
Journal of Sulfur Chemistry
Journal of Sulfur Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.10
自引率
9.10%
发文量
38
审稿时长
6-12 weeks
期刊介绍: The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science. Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.
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