SARS-CoV-2感染重症病例多器官病理实验室标志物及不良结局(系统评价)

N. A. Konyshko, L. I. Volynets, G. S. Konyshko
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引用次数: 0

摘要

该综述的目的是:提供与严重SARS-CoV-2感染和内脏损伤相关的患者实验室参数的最新科学信息。材料和方法:分析2019年至2022年期间来自PubMed、Elsevier、Scopus、Google Scholar、E-library等科学数据库的临床、随机和队列研究全文、系统评价和荟萃分析。结果。确定了特异性生物标志物,包括炎症和免疫参数(c反应蛋白、降钙素原、IL6)、血液学参数(淋巴细胞和中性粒细胞数量、NLR、d -二聚体、铁蛋白、RDW)、心肌参数(肌钙蛋白、肌动激酶mb、肌红蛋白)、肝脏参数(AST、ALT、总胆红素、白蛋白)和肺损伤特征(KL-6),这些可用于风险分层,作为COVID-19患者不良临床后果(包括死亡)的预后生物标志物。这些研究发现了covid - 19炎症和全身表现的新生物标志物:降钙素原、钙保护素和高血压素。
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Laboratory markers of multiple organ pathology in severe cases and adverse outcomes of SARS-CoV-2 infection (systematic review)
The aim of the review: to present up-to-date scientifically based information about the laboratory parameters of patients associated with severe SARS-CoV-2 infection and internal organ damage. Materials and methods: full-text publications of clinical, randomized and cohort studies, systematic reviews and meta-analyses from scientific databases PubMed, Elsevier, Scopus, Google Scholar, E-library for the period from 2019 to 2022 were analyzed. Results. Specific biomarkers were identified, including inflammatory and immunological parameters (C-reactive protein, procalcitonin, IL6), hematological (number of lymphocytes and neutrophils, NLR, D-dimer, ferritin, RDW), myocardial (troponin, creatinekinase-MB, myoglobin), hepatic (AST, ALT, total bilirubin, albumin) and characterizing lung injury (KL-6), which can be used for risk stratification, as prognostic biomarkers of adverse clinical consequences, including death in patients with COVID-19. The studies demonstrated new biomarkers of inflammatory and systemic manifestations of COVID19: procalcitonin, calprotectin and presepsin.
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来源期刊
Jurnal Infektologii
Jurnal Infektologii Medicine-Infectious Diseases
CiteScore
0.80
自引率
0.00%
发文量
52
审稿时长
8 weeks
期刊介绍: The purposes of the journal are to describe modern achievements in the study of infectious diseases, and in related sciences as well; to promote the exchange of clinical experience among the experts; to publish the results of clinical research of medical products and medical equipment; to give the information on medical congresses on infectious diseases as well as other significant events in the field of modern infectology in our country and abroad.
期刊最新文献
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