microRNA与睾丸癌诊断和预后的关系:一项系统综述

Antonio J. URIBE BAYONA, Maria J. CHAVES MEDINA, Herney A. GARCÍA-PERDOMO
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引用次数: 0

摘要

背景:探讨睾丸生殖细胞肿瘤中最常见的miRNA表达评估与早期诊断和预后的关系。方法:我们制定了一项搜索策略,包括与睾丸癌和miRNA作为诊断工具相关的最重要数据库(Medline、Embase、LILACS、Central)中的临床试验、准实验、队列、病例对照和横断面研究。结果:我们发现了17项符合纳入和排除标准的研究,对1816例具有多种miRNA的患者进行了评估,但更频繁地观察了miRNA 371、372和373,发现这些miRNA与睾丸肿瘤诊断之间存在重要关系。结论:mi-RNA 371有很好的证据支持其在睾丸肿瘤诊断中的应用。
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Association between microRNA and the diagnosis and prognosis of testicular cancer: a systematic review
BACKGROUND: To determine the association between the most common miRNA expression assessment and early diagnosis and prognosis in testicular germ cell tumors.METHODS: We developed a search strategy including clinical trials, quasi-experiments, cohort, case-control, and cross-sectional studies in the most critical databases (Medline, Embase, LILACS, Central) related to testicular cancer and miRNA as diagnostic tools.RESULTS: We found 17 studies that fulfilled the inclusion and exclusion criteria, with 1816 patients with multiple miRNAs assessed but more frequently looked at the miRNA 371, 372, and 373, finding an important relation between these mi-RNA and diagnosis of testicular tumors.CONCLUSIONS: mi-RNA 371 has good evidence that favors its use in diagnosing testicular tumors.
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来源期刊
Rivista Italiana della Medicina di Laboratorio
Rivista Italiana della Medicina di Laboratorio Health Professions-Medical Laboratory Technology
CiteScore
0.80
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0.00%
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28
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