基于免疫的、多方面的致病性T淋巴细胞失活治疗自身免疫性疾病

Victor Ivanovich Seledtsov, Galina V. Seledtsova, Alexei A. von Delwig
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引用次数: 0

摘要

自身免疫性疾病的免疫治疗应旨在灭活自身侵袭性记忆t细胞并恢复免疫耐受。设想有三种方法可用于实现这一目标:通过接种致病性t细胞刺激抗独特型免疫反应;针对两种或多种表面t细胞标记物给予次优剂量的抗体(Abs),以提供选择性的抗体介导的活化致病性记忆t细胞的破坏;并诱导口腔免疫耐受。该建议需要使用t细胞疫苗接种(TCV)或基于抗体的治疗作为减少自身抗原t细胞致敏的初始方法。随后,建议实施口服免疫疗法(OIT)以恢复一致的免疫耐受。
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Immune-based, multifaceted inactivation of pathogenic T lymphocytes in treating autoimmune diseases
Immunotherapeutic treatment of autoimmune diseases should aim to inactivate autoaggressive memory T-cells and restore immune tolerance. It is envisaged that three approaches could be used to achieve this goal: stimulation of anti-idiotypic immune responses by vaccination with pathogenic T-cells; administration of suboptimal doses of antibodies (Abs) against two or more surface T-cell markers to provide selective Ab-mediated destruction of activated pathogenic memory T-cells; and induction of oral immune tolerance. The proposal entails the use of T-cell vaccination (TCV) or Ab-based therapy as an initial approach to reduce autoantigenic T-cell sensitization. Subsequently, the implementation of oral immunotherapy (OIT) is recommended to reinstate a consistent immune tolerance.
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