肿瘤微环境在膀胱癌发生和发展中的机制和作用

Na Cui, Yajun Shi, Yi Ding, Yanhua Wang
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引用次数: 0

摘要

肿瘤微环境(Tumor microenvironment, TME)是一个由肿瘤细胞、肿瘤相关基质细胞、免疫细胞以及这些细胞分泌的细胞因子和趋化因子组成的巨大网络,在这个网络中,各种细胞之间相互交流。由于TME的作用,膀胱癌具有复发、进展、转移的特点。近年来,随着肿瘤体rna测序和单细胞转录组测序等新技术的应用和发展,膀胱癌TME的组成越来越清晰,复杂的细胞间通讯网络被充分挖掘,这为膀胱癌的治疗提供了新的视野。本文在总结膀胱癌细胞成分和细胞外基质成分最新研究进展的基础上,综述并进一步分析了膀胱癌细胞成分和细胞外基质成分的研究热点。
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Mechanism and Role of Tumor Microenvironment in the Initiation and Progression of Bladder Cancer
Tumor microenvironment (TME) is a huge network, composed by tumor cells, tumor associated stromal cells, immune cells, cytokines and chemokines secreted by these cells, in which various cells communicate with each other. Bladder cancer is characterized of tendency of relapse, progression, metastasis because of the role of TME. With the application and development of new technologies recently, such as tumor bulk RNA-sequencing and single-cell transcriptome sequencing, the composition of TME for bladder cancer is increasingly clear and the complex cell-to-cell communication network is fully duged, which provides a new vision for the therapy of bladder cancer. This paper reviewed and further analysed the research hotspots of cellular components and extracellular matrix components of bladder cancer on the basis of the latest research progress.
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