可能的漏诊:风疹病毒淋巴结炎,一种重新唤醒的流行病

Sinem Eser POLAT ÜNAL, Sultan AYDİN KÖKER, Dinç SÜREN
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引用次数: 0

摘要

由于在消灭麻疹后,在我国没有观察到麻疹感染,特别是在迁移后再次出现麻疹感染,病理学家可能会发现在组织病理学上识别疹疹淋巴结炎病例并建立准确的诊断是具有挑战性的。在此,我们描述一个罕见的风疹病例的组织病理学特征。一名15岁的叙利亚男性移民患者因耳后区淋巴结肿胀2个月而入院。初步诊断为淋巴瘤,行淋巴结切除。本诊所对切除淋巴结进行常规病理检查。组织病理学检查显示,淋巴结内厚纤维囊下保留了基本结构。warthin - finkeldey型巨细胞在滤泡间区引起注意。未见与淋巴增生性肿瘤相符的外观。经检查发现风疹IgM阳性,告知相关诊所有风疹淋巴结炎的组织学征象,评估为风疹感染。在疫苗发明之前的一个世纪里,风疹是一种常见的致命传染病。今天,由于对疫苗的犹豫、移民和社会文化条件,又发生了一场流行病。因为它是非常罕见的,我们希望我们提出的病例将为病理学家提供见解,以识别Rubeola淋巴结炎的病例和做出准确的诊断。
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MUHTEMELEN ATLANILAN BİR TANI: RUBEOLA LENFADENİTİ, YENİDEN ALARM VEREN BİR SALGIN
Because Rubeola (measles) infection is not observed in our country after eradication and is especially on the agenda again after migrations, pathologists may find it challenging to histopathologically recognize cases of Rubeola lymphadenitis and establish an accurate diagnosis. Here we describe the histopathological features of a rare Rubeola case. A 15-year-old Syrian migrant male patient was admitted with a complaint of lymph node swelling in the postauricular region for 2 months. Lymph node excision was performed with a preliminary diagnosis of lymphoma. The excised lymph node was subjected to a routine pathological examination in our clinic. Histopathological examination revealed that the basic structure was preserved under the thick fibrous capsule in the lymph node. Warthin-Finkeldey-type giant cells attracted attention in the interfollicular areas. The appearance compatible with lymphoproliferative neoplasia was not detected. The relevant clinic was informed that there were histological signs of Rubeola lymphadenitis upon detection of Rubeola IgM positivity in the examination, the case was evaluated as Rubeola infection. Rubeola was a common deadly infectious disease in the past century before the vaccine was developed. Today, there has been an epidemic again due to vaccine hesitancy, migration, and sociocultural conditions. Because it is exceptionally rare, we hope that the case we present will provide insights to pathologists for recognizing cases of Rubeola lymphadenitis and making precise diagnoses.
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