Murine Models of Infantile Hemangioma: A Comprehensive Review

Infantile hemangioma is the most common benign vascular tumor of infancy and is characterized by a unique life cycle. Animal models that reflect the histological and biological characteristics of infantile hemangioma are critical tools for preclinical studies. Various infantile hemangioma animal models have been developed and improved during the past few decades. However, very few reports have provided practical suggestions for selecting a suitable animal model based on the study purpose. This comprehensive review summarizes the construction methods and application scenarios of different models. The advantages and disadvantages of each model are fully discussed, providing a reference for choosing the most applicable animal model for infantile hemangioma-associated research.