葡萄糖酸奥拉西定和聚维酮碘治疗胃肠道手术后手术部位感染的随机对照试验

IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of Gastroenterological Surgery Pub Date : 2023-09-09 DOI:10.1002/ags3.12739
Hiroya Iida, Hiromitsu Maehira, Sachiko Kaida, Katsushi Takebayashi, Toru Miyake, Masaji Tani
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引用次数: 0

摘要

目的 手术部位使用的抗菌剂对预防手术部位感染(SSI)至关重要。本研究对新型防腐剂葡萄糖酸奥拉西定(OG)和聚维酮碘(PI)进行了比较研究,以确定 OG 是否比 PI 更有效地预防胃肠道手术后的 SSI。 方法 这项前瞻性、随机、单盲、介入性单中心研究于 2018 年 8 月至 2021 年 2 月期间进行。计划接受大型胃肠道手术的患者被随机分为两组,分别使用 OG(OG 组)或 PI(PI 组)作为术前抗菌剂。主要终点是术后 30 天内的 SSI 发生率。 结果 总共有 525 名患者参与了这项研究,其中 OG 组和 PI 组分别有 256 名和 254 名患者。OG 组(10.8%;n = 26)和 PI 组(13.0%;n = 33)的总 SSI 发生率无显著差异(p = 0.335)。浅切口 SSI 和器官/间隙 SSI 的发生率在各组间无显著差异;但深切口 SSI 的发生率有显著差异,OG 组为 0.4%(n = 1),PI 组为 4.3%(n = 11)(p = 0.003)。 结论 OG 作为一种术前皮肤消毒剂,并没有降低总 SSI 的发生率。不过,使用 OG 可减少深切口 SSI。
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Randomized controlled trial of olanexidine gluconate and povidone iodine for surgical site infection after gastrointestinal surgery

Aim

Antiseptics used at surgical sites are vital to preventing surgical site infections (SSI). In this study, a comparative investigation of the novel antiseptics olanexidine gluconate (OG) and povidone-iodine (PI) was conducted to determine whether OG is more effective than PI against SSI after gastrointestinal surgery.

Methods

This prospective, randomized, single-blind, interventional, single-center study was conducted between August 2018 and February 2021. Patients scheduled for large-scale gastrointestinal surgeries were randomized into two groups and administered OG (OG group) or PI (PI group) as preoperative antiseptics. The primary endpoint was the SSI occurrence rate within 30 days after surgery.

Results

In total, 525 patients were enrolled in this study, of whom 256 and 254 were in the OG and PI groups, respectively. The total SSI occurrence rate in the OG group (10.8%; n = 26) and the PI group (13.0%; n = 33) was not significantly different (p = 0.335). The occurrence rate of superficial incisional SSI and organ/space SSI did not significantly differ between the groups; however, that of deep incisional SSI showed a significant difference, with 0.4% (n = 1) in the OG group and 4.3% (n = 11) in the PI group (p = 0.003).

Conclusion

OG, as a preoperative skin antiseptic, did not reduce the occurrence rate of total SSI. However, deep incisional SSI may be reduced using OG.

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来源期刊
Annals of Gastroenterological Surgery
Annals of Gastroenterological Surgery GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.30
自引率
11.10%
发文量
98
审稿时长
11 weeks
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